Upptäck den läkande
kraften hos Ultrawater
och joniserat H₂ vatten

Vad gör Livsvatten unikt?

Bättre vattenrening

Bättre vatten

Bäst teknologi

INTE BARA RENT -ULTRARENT

VATTENRENING DU KAN LITA PÅ

Trygghet är säkerheten som våra UltraWater filter ger dig. Stöds av trovärdiga EPAcertifierade laboratorietester där i princip alla 249 föroreningar minskade till 99,9%

SE HUR ULTRAWATER FUNGERAR

AKTIVERA DITT VATTEN MED H2

H2 ÄR VÄRLDENS KRAFTFULLASTE ANTIOXIDANT

Basisk balans är HÄLSA! Aktivering av H2 och högre pH i ditt vatten skapar enorm läkningspotential

Detta gör H2

VI SÄTTER GRÄNSERNA

Kraftfullhet och Enkelhet

Ultrawater filterserie som gör vattnet Ultrarent. DARKII teknolgi som renar samtidigt som din vattenrenare joniserar vattnet. Värmeskydd, Möjlighet till filterpatroner som tillför mineraler och mycket mer

Se skillnaden mot våra konkurrenter

Utvalda Produkter

Vesta H2 
Kraftfull. Smart 

Oöverträffad prestanda med Ultrawater filtrering. 9 st smart electrodes. H2 fusionsteknik och förbättrad Dark II rengöring

Vår kraftfullaste bänkmodell

Delbetala med KLARNA

Bänkmodell H2
Ultrarent. Ultrasnygg

Diskbänksmodell H2 smälter in i alla kök. Integrerad Ultrawater ger optimal filtrering, joniserar och skapar basisk, H2 förbättrat vatten.

Delbetala med KLARNA

Delphi H2
Kraftfull Design

Oöverträffad prestanda med Ultrawater filtrering. 9 st smart electrodes. H2 fusionsteknik och förbättrad Dark II rengöring

Det sofistikerade valet

Delbetala med KLARNA

Melody
Effektiv. Smart

Mycket bra prestanda med Ultrawater filtrering. 5 st smart electrodes. H2 fusionsteknik och förbättrad Dark II rengöring.

Premium modell som har allt

Delbetala med KLARNA

Finance for as low as $ 17 / month . Get Pre-Approved

Ersättningsfilter

The toggles are working. Please, note, that you have to add a template to the library in order to be able to display it inside the toggles.

Ersättningsfilter

Hur fungerar en Vattenjonisator?

Vi gör mer med ditt vatten!

SE HUR EN VATTENJONISATOR FUNGERAR

Vi ger mer än bara vattenrening..

Smartare, bättre, hälsosammare. och lite till..

Tyvärr har många väldigt låga krav på sin vattenkälla:

Här stannar dom flesta vid sitt val av vattenkälla...

DITT VATTEN HAR MER ATT GE!

Du får 5 olika typer av vatten
med en vattenjonisator

LÄS MER =>

Vad vill du göra med ditt vatten?

Med en vattenjonisator får du 5 olika typer av vatten

Livsvattens innovativa H2 jonisatorer filtrerar inte bara kranvattnet utan de producerar joniserat alkaliskt och surt vatten genom elektrolys. Du får 5 olika vatten där du kan göra helt nya saker du inte trodde var möjligt med vatten. Dessa olika vatten kan användas för olika ändamål, inklusive dryck, matlagning, skönhetsvård och rengöring. Detta gör att kemikalieanvändningen minskar, du får en mer naturlig livsstil och sparar pengar i produkter du kanske inte behöver lika mycket av längre. 

pH 11

Starkt basiskt vatten

Används ej för att dricka. Starkt Basiskt vatten bevarar hygienen i ditt dagliga liv på grund av dess starka rengöringseffekt. Det har upplösande och värmeledande fördelar. Användning: matlagning och rengöring.

Matlagning

Lägg dina grönsaker/ frukter i starkt basist vatten så de infusioneras med H2 som stärker livslängden och gör allt mer smakrikt och vitalt. De blir mer smakrika med sötare smak.

Rawfood

Greenspulver: Lägg vetegräspulver, chlorella mm i starkt basiskt vatten och vänta i 30 sekunder. Spä sedan ut den med vanligt basiskt vatten eller lägg den i en dryck eller smoothie. Kinesiologitester visar att man får vetegräs som har starkare effekt än om den vore färskpressad! Du sparar med andra ord tid och massa möda och kan enkelt maximera egenskaperna ur dina bästa greenspulver 

Rengöring

Rengör skärbrädor och diskdukar. Bra för rengöring av olja och hård smuts från ventiler samt för allmän rengöring i köket.

Fläckar

Den extra styrkan i starkt basikst vatten kan hjälpa att bort kaffe, sojasås och oljefläckar. Också bra för att få bort envisa toalettskålfläckar.

pH 8-9,5

Basiskt vatten

Denna typ av vatten är perfekt för att dricka och för hälsosam matlagning. Det är negativt laddat och vätetrikt H2 vatten som hjälper att återställa kroppen till ett mer basiskt tillstånd, vilket är optimalt och normalt för god hälsa. 
Användningsområde: dricka, matlagning, kaffe och te, soppor och grytor och vattna växter.

Dricka

Drick basiskt H2 vatten under hela dagen mellan måltider. Till skillnad från kranvatten har basiskt vatten ingen obehaglig lukt, smakar lättare och har en behagligt söt smak. Undvik att dricka basiskt H2 vatten under måltider då kroppen skall ha en sur miljö för att smälta maten och att basiskt vatten komplicerar detta. Drick pH neutralt vatten till maten istället! Det bästa är dricka basiskt 30 minuter innan och 2h efter en måltid. 
Prova att dricka basiskt vatten mot eventuellt sötsug! Det brukar minimera suget.

Matlagning

Rengör grönsaker och fisk. Förbättra smaken på broccoli, lök, bambu etc. genom att förkoka dem i basiskt H2 vatten. Du kan normalt använda mindre kryddor och salt i maten när H2 vatten används i den.

Kaffe och te

Du blir förvånad över den underbara färgen, smaken och aromen av kaffe eller te tillagat med joniserat basiskt vatten. Du kan oftast använda mindre kaffe eller te och ändå uppnå en full rik smak på grund av vattnets upplösande förmåga.

Soppor

Basiskt H2 vatten drar fram smaken på ingredienser så att de blir mjuka och saftiga. Därför behöver inte mat så mycket smaksättning, och överskott av salt kan undvikas

Växter

Basiskt H2 vatten kan ge växter friskhet och liv. Vattnet stimulerar groddar och förbättrar utvecklingen av plantor. Notera att vissa växter föredrar surt vatten och då använder du det sura joniserade vattnet till dom!

pH 7

Rent vatten

Rent vatten fritt från läkemedelsrester, tungmetaller, klor, rost och annat skadligt innehåll. Då Ultrawater tar bort det mesta till 99,9 % vilket ger dig ett rent pH neutralt vatten som är läckert gott dricksvatten under en måltid. Användning: Förbereda barnmat, Medicinintag.

Barnmat

Använd vatten pH 7,0 när du förbereder barnmat.

Medicinintag

Mediciner skall tas med neutralt vatten då basiskt vatten kan accelerera mediciners verkan på ett negativt sätt.

pH 5,5

Surt vatten

Används ej som dricksvatten. Detta svagt sura vatten är känt för sin sammandragande effekter. Det är fantastiskt att använda för skonsam rengöring och skönhetsvård. Användning: Ansiktstvätt, hårvård, vård av husdjur, polering, rengöring och konservering av frysta livsmedel.

Ansiktstvätt

De sammandragande egenskaperna hos surt vatten är effektiva vid toning och förstärkning av din hud. Klappa huden och låt torka. Kunder har rapporterat att mollusker försvinner vid användande. Detta vatten är också utmärkt som toner efter rakning.

Hårvård

Använd detta vatten istället för balsam efter schamponering. Minskar irriterande trasslar och får fram en strålande glans. Förvara i en sprayflaska och spraya håret och ansiktet när du är ute och går. Du kan även spraya detta vatten på ditt husdjurs päls för att få den blank och len.

Frysa in mat

Spraya surt vatten på livsmedel vid infrysning så att maten, t.ex fisk och räkor, inte tappar smaken när den tinas ut.

pH 5,5

Starkt surt vatten

Inte drickbart. Detta vatten har steriliserande och desinficerande egenskaper. Använd starkt surt vatten för att sanera köksredskap, bänkskivor och för att förhindra bakteriekontaminering. Användningsområde: rengöring och desinfektion, hygien.

Desinfektion

Sanera knivar, skärbrädor, handdukar och köksdukar etc. Rengör och desinficera utan kemikalier i och runt köket, som är en grogrund för bakterier.
 
 

Hygien

Desinficera dina händer, din tandborste eller använd som muntvätt efter en tandborstning. Förvara ditt vatten en sprayflaska i ditt badrum för enkel åtkomst men kom ihåg att byta ut det varannan dag.
 

I din verksamhet

SPA, Skönhetssalonger, frisörsalonger, restauranger, daghem, husdjursbutiker och vårdhem har alla stor nytta av användningen av starkt surt vatten men även basiskt vatten till sina klienter.

Välkommen till vår värld. Vi har inga tvivel på att joniserat vatten är bäst för din hälsa. Det inser du själv när du ser vad över 1000 vetenskapliga studier säger om joniserat h2 vatten.
Våra vattenrenare förändrar ditt vatten och vi förändrar sättet du ser på vatten!

1000 tals studier om H₂ vatten
kan inte ha fel. 

FORSKNINGSRÖN OM H₂

1000 tals studier om H2 vatten har inte fel. 
Se vad H2 kan hjälpa mot enligt de senaste forskningsrönen:

Klicka för att se alla studier!

Kliniska studier på joniserat H2 vatten

De sista åren har det skett ett enormt uppsving i studier av joniserat H2 vatten runt om i världen. Här följer några utan speciell rangordning men klassade i kroppens områdesfält. Längre ner på sidan under dessa olika områden finns även studier som har tagits fram med ursprungstexten skriven i studien. Detta är de olika områden som studerats: 
 
  • SHIRAHATA, S., KABAYAMA, S., NAKANO, M., MIURA, T., KUSUMOTO, K., GOTOH, M., HAYASHI, H., OTSUBO, K., MORISAWA, S. u0026amp; KATAKURA, Y. (1997). Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage. Biochemical and Biophysical Research Communications 234, 269-274.
  • HANAOKA, K., SUN, D. X., LAWRENCE, R., KAMITANI, Y. u0026amp; FERNANDES, G. (2004). The mechanism of the enhanced antioxidant effects against superoxide anion radicals of reduced water produced by electrolysis. Biophysical Chemistry 107, 71-82.
  • HIRAOKA, A., TAKEMOTO, M., SUZUKI, T., SHINOHARA, A., CHIBA, M., SHIRAO, M. u0026amp; YOSHIMURA, Y. (2004). Studies on the properties and real existence of aqueous solution systems that are assumed to have antioxidant activities by the action of “active hydrogen”‘. Journal of Health Science 50, 456-465.
  • PARK, E. J. (2005). Protective effect of electrolyzed reduced water on the paraquat-induced oxidative damage of human lymphocyte DNA. Journal of the Korean Society for Applied Biological Chemistry 48, 155-160.
  • YANAGIHARA, T., ARAI, K., MIYAMAE, K., SATO, B., SHUDO, T., YAMADA, M. u0026amp; AOYAMA, M. (2005). Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: a feeding test with rats. Biosci Biotechnol Biochem 69, 1985-7.
  • LEE, M. Y., KIM, Y. K., RYOO, K. K., LEE, Y. B. u0026amp; PARK, E. J. (2006). Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein. Appl Biochem Biotechnol 135, 133-44.
  • OHSAWA, I., ISHIKAWA, M., TAKAHASHI, K., WATANABE, M., NISHIMAKI, K., YAMAGATA, K., KATSURA, K., KATAYAMA, Y., ASOH, S. u0026amp; OHTA, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13, 688-694.
  • HANXU YAN, H. T., TAKEKI HAMASAKI, MASUMI ABE, NOBORU NAKAMICHI, KIICHIRO TERUYA, YOSHINORI KATAKURA, SHINKATSU MORISAWA, SANETAKA SHIRAHATA. (2010). electrolyzed reduced water prolongs caenorhabditis elegans lifespan. Animal Cell Technology: Basic u0026amp; Applied Aspects 16, 289-293.
  • HIRAOKA, A., INABA, H., SUZUKI, E., KASAI, K., SUZUKI, H., SHINOHARA, A., SHIRAO, M., KUBO, K. u0026amp; YOSHIMURA, Y. (2010). In Vitro Physicochemical Properties of Neutral Aqueous Solution Systems (Water Products as Drinks) Containing Hydrogen Gas, 2-Carboxyethyl Germanium Sesquioxide, and Platinum Nanocolloid as Additives. Journal of Health Science 56, 167-174.
  • YAN, H. X., TIAN, H. Z., KINJO, T., HAMASAKI, T., TOMIMATSU, K., NAKAMICHI, N., TERUYA, K., KABAYAMA, S. u0026amp; SHIRAHATA, S. (2010). Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water. Bioscience Biotechnology and Biochemistry 74, 2011-2015.
  • BERJAK, P., SERSHEN, VARGHESE, B. u0026amp; PAMMENTER, N. W. (2011). Cathodic amelioration of the adverse effects of oxidative stress accompanying procedures necessary for cryopreservation of embryonic axes of recalcitrant-seeded species. Seed Science Research 21, 187-203.
  • YAN, H., KINJO, T., TIAN, H., HAMASAKI, T., TERUYA, K., KABAYAMA, S. u0026amp; SHIRAHATA, S. (2011). Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water–participation of Pt nanoparticles. Bioscience, Biotechnology, and Biochemistry 75, 1295-9.
  • PARK, S. K., KIM, J. J., YU, A. R., LEE, M. Y. u0026amp; PARK, S. K. (2012). Electrolyzed-reduced water confers increased resistance to environmental stresses. Molecular u0026amp; Cellular Toxicology 8, 241-247.
  • JIN, Q., ZHU, K., CUI, W., XIE, Y., HAN, B. u0026amp; SHEN, W. (2013). Hydrogen gas acts as a novel bioactive molecule in enhancing plant tolerance to paraquat-induced oxidative stress via the modulation of heme oxygenase-1 signalling system. Plant Cell and Environment 36, 956-69.
  • QIAN, L., MEI, K., SHEN, J. u0026amp; CAI, J. (2013). Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD). Transplantation 95, 658-62.
 
  • HUANG, K. C., YANG, C. C., LEE, K. T. ; CHIEN, C. T. (2003). Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney Int 64, 704-14.
  • HIRAOKA, A., SASAKI, S., YAMADA, T., SHINOHARA, A. ; CHIBA, M. (2006). Effects of drinking a water product with anti-oxidant activities in vitro on the blood levels of biomarker substances for the oxidative stress. Journal of Health Science 52, 817-820.
  • HUANG, K. C., YANG, C. C., HSU, S. P., LEE, K. T., LIU, H. W., MORISAWA, S., OTSUBO, K. u0026amp; CHIEN, C. T. (2006). Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients. Kidney Int 70, 391-8.
  • LU, K. C., TSENG, C. F., YEUNG, L. K., HSU, S. P. u0026amp; CHIEN, C. T. (2006). Electrolyzed reduced water attenuates hemodialysis-induced mononuclear cells apoptosis in end-stage renal disease patients. Nephrology Dialysis Transplantation 21, 200-201.
  • YEUNG, L. K., LU, K. C., TSENG, C. F., HSU, S. P. & CHIEN, C. T. (2006). Effect of electrolyzed reduced water hemodialysis on peripheral lymphocyte intracellular cytokine expression. Nephrology Dialysis Transplantation 21, 204-204.
  • KAJIYAMA, S., HASEGAWA, G., ASANO, M., HOSODA, H., FUKUI, M., NAKAMURA, N., KITAWAKI, J., IMAI, S., NAKANO, K., OHTA, M., ADACHI, T., OBAYASHI, H. u0026amp; YOSHIKAWA, T. (2008). Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research 28, 137–143.
  • KOYAMA K, T. Y., SAIHARA Y, ANDO D, GOTO Y, KATAYAMA A. (2008). Effect of hydrogen saturated alkaline electrolyzed water on urinary oxidative stress markers after an acute exercise: A randomized controlled trial. Anti-aging Med 4, 117-122.
  • NAKAYAMA, M., KABAYAMA, S., NAKANO, H., ZHU, W. J., TERAWAKI, H., NAKAYAMA, K., KATOH, K., SATOH, T. & ITO, S. (2009). Biological Effects of Electrolyzed Water in Hemodialysis. Nephron Clinical Practice 112, C9-C15.
  • HUANG, K. C., HSU, S. P., YANG, C. C., PU, O. Y., LEE, K. T., MORISAWA, S., OTSUBO, K. & CHIEN, C. T. (2010). Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis. Nephrology Dialysis Transplantation 25, 2730-2737.
  • NAKAO, A., TOYODA, Y., SHARMA, P., EVANS, M. & GUTHRIE, N. (2010). Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study. Journal of Clinical Biochemistry and Nutrition 46, 140-149.
  • NAKAYAMA, M., NAKANO, H., HAMADA, H., ITAMI, N., NAKAZAWA, R. & ITO, S. (2010). A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial. Nephrology Dialysis Transplantation 25, 3026-3033.
  • ITO, M., IBI, T., SAHASHI, K., ICHIHARA, M. & OHNO, K. (2011). Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Medical Gas Research 1, 24.
  • KANG, K.-M., KANG, Y.-N., CHOI, I.-B., GU, Y., KAWAMURA, T., TOYODA, Y. & NAKAO, A. (2011). Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research 1, 11.
  • OSTOJIć, S. M., STOJANOVIć, M. D., CALLEJA-GONZALEZ, J., OBRENOVIć, M. D., VELJOVIć, D., MEđEDOVIć, B., KANOSTREVAC, K., STOJANOVIć, M. & VUKOMANOVIć, B. (2011). Drinks with alkaline negative oxidative reduction potential improve exercise performance in physically active men and women: Double-blind, randomized, placebo-controlled, cross-over trial of efficacy and safety. Serbian journal of sports sciences 5, 83-89.
  • AOKI, K., NAKAO, A., ADACHI, T., MATSUI, Y. & MIYAKAWA, S. (2012). Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research 2, 12.
  • ISHIBASHI, T., SATO, B., RIKITAKE, M., SEO, T., KUROKAWA, R., HARA, Y., NARITOMI, Y., HARA, H. & NAGAO, T. (2012). Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study. Medical Gas Research 2, 27.
  • ONO, H., NISHIJIMA, Y., ADACHI, N., SAKAMOTO, M., KUDO, Y., KANEKO, K., NAKAO, A. & IMAOKA, T. (2012). A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Medical Gas Research 2, 21.
  • ONO, H., NISHIJIMA, Y., ADACHI, N., SAKAMOTO, M., KUDO, Y., NAKAZAWA, J., KANEKO, K. & NAKAO, A. (2012). Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Medical Gas Research 2, 14.
  • MATSUMOTO, S., UEDA, T. & KAKIZAKI, H. (2013). Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology 81, 226-30.
  • P., D., OSTOJIC, S. M., M., S. ; T., A. T. (2013). Hydrogen-Rich Water in Judo Training. . Psycho-Physiological, Spiritual and Ethical Aspects), 129.
  • SHIN, M. H., PARK, R., NOJIMA, H., KIM, H. C., KIM, Y. K.; CHUNG, J. H. (2013). Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo. PLoS One 8, e61696.
  • TERAWAKI, H., HAYASHI, Y., ZHU, W. J., MATSUYAMA, Y., TERADA, T., KABAYAMA, S., WATANABE, T., ERA, S., SATO, B. ; NAKAYAMA, M. (2013). Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Medical Gas Research 3, 14.
  • YORITAKA, A., TAKANASHI, M., HIRAYAMA, M., NAKAHARA, T., OHTA, S.: HATTORI, N. (2013). Pilot study of H(2) therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial. Movement Disorders.
 
  • KIKKAWA, Y. S., NAKAGAWA, T., HORIE, R. T. u0026amp; ITO, J. (2009). Hydrogen protects auditory hair cells from free radicals. Neuroreport 20, 689-94.
  • OHARAZAWA, H., TSUTOMU IGARASHI, TAKASHI YOKOTA, HIROAKI FUJII, HISAHARU SUZUKI, MITSURU MACHIDE, HIROSHI TAKAHASHI, SHIGEO OHTA, AND IKUROH OHSAWA. (2010). Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia–reperfusion injury. Investigative ophthalmology u0026amp; visual science 51, 487-492.
  • OHARAZAWA, H., IGARASHI, T., YOKOTA, T., FUJII, H., SUZUKI, H., MACHIDE, M., TAKAHASHI, H., OHTA, S. u0026amp; OHSAWA, I. (2010). Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia-Reperfusion Injury. Investigative Ophthalmology u0026amp; Visual Science 51, 487-492.
  • TAURA, A., KIKKAWA, Y. S., NAKAGAWA, T. u0026amp; ITO, J. (2010). Hydrogen protects vestibular hair cells from free radicals. Acta Oto-Laryngologica 130, 95-100.
  • LIN, Y., KASHIO, A., SAKAMOTO, T., SUZUKAWA, K., KAKIGI, A. u0026amp; YAMASOBA, T. (2011). Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neuroscience Letters 487, 12-16.
  • FENG, M., WANG, X. H., YANG, X. B., XIAO, Q. u0026amp; JIANG, F. G. (2012). Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats. Int J Ophthalmol 5, 151-7.
  • HUANG, L., ZHAO, S., ZHANG, J. H. u0026amp; SUN, X. (2012). Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. Ophthalmic Res 47, 122-7.
  • QU, J., GAN, Y. N., XIE, K. L., LIU, W. B., WANG, Y. F., HEI, R. Y., MI, W. J. u0026amp; QIU, J. H. (2012). Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils. Acta Pharmacologica Sinica 33, 445-451.
  • QU, J., LI, X., WANG, J., MI, W., XIE, K. u0026amp; QIU, J. (2012). Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress. Int J Pediatr Otorhinolaryngol 76, 111-5.
  • ZHOU, Y., ZHENG, H., RUAN, F., CHEN, X., ZHENG, G., KANG, M., ZHANG, Q. u0026amp; SUN, X. (2012). Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs. Neuroscience 209, 47-53.
 
  • WATANABE, T., KISHIKAWA, Y. u0026amp; SHIRAI, W. (1997). Influence of alkaline ionized water on rat erythrocyte hexokinase activity and myocardium. J Toxicol Sci 22, 141-52.
  • WATANABE, T. u0026amp; KISHIKAWA, Y. (1998). Degradation of myocardiac myosin and creatine kinase in rats given alkaline ionized water. J Vet Med Sci 60, 245-50.
  • WATANABE, T., SHIRAI, W., PAN, I., FUKUDA, Y., MURASUGI, E., SATO, T., KAMATA, H. u0026amp; UWATOKO, K. (1998). Histopathological influence of alkaline ionized water on myocardial muscle of mother rats. J Toxicol Sci 23, 411-7.
  • QIAN, L. R., CAO, F., CUI, J. G., WANG, Y. C., HUANG, Y. C., CHUAI, Y. H., ZAHO, L. Q., JIANG, H. u0026amp; CAI, J. M. (2010). The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice. Journal of Radiation Research 51, 741-747.
  • HAYASHI, T., YOSHIOKA, T., HASEGAWA, K., MIYAMURA, M., MORI, T., UKIMURA, A., MATSUMURA, Y. u0026amp; ISHIZAKA, N. (2011). Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. American Journal of Physiology – Heart and Circulatory Physiology 301, H1062-9.
  • KASUYAMA, K., TOMOFUJI, T., EKUNI, D., TAMAKI, N., AZUMA, T., IRIE, K., ENDO, Y. u0026amp; MORITA, M. (2011). Hydrogen-rich water attenuates experimental periodontitis in a rat model. J Clin Periodontol 38, 1085-90.
  • HAYASHIDA, K., SANO, M., KAMIMURA, N., YOKOTA, T., SUZUKI, M., MAEKAWA, Y., KAWAMURA, A., ABE, T., OHTA, S., FUKUDA, K. u0026amp; HORI, S. (2012). H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc 1, e003459.
  • NODA, K., TANAKA, Y., SHIGEMURA, N., KAWAMURA, T., WANG, Y., MASUTANI, K., SUN, X., TOYODA, Y., BERMUDEZ, C. A. u0026amp; NAKAO, A. (2012). Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int 25, 1213-22.
  • QIN, Z. X., YU, P., QIAN, D. H., SONG, M. B., TAN, H., YU, Y., LI, W., WANG, H., LIU, J., WANG, Q., SUN, X. J., JIANG, H., ZHU, J. K., LU, W. u0026amp; HUANG, L. (2012). Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-alpha/NF-kappaB pathway. Atherosclerosis 220, 343-50.
  • SAKAI, K., CHO, S., SHIBATA, I., YOSHITOMI, O., MAEKAWA, T. u0026amp; SUMIKAWA, K. (2012). Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. Scandinavian Cardiovascular Journal 46, 183-9.
  • SUN, Q., KAWAMURA, T., MASUTANI, K., PENG, X., STOLZ, D. B., PRIBIS, J. P., BILLIAR, T. R., SUN, X., BERMUDEZ, C. A., TOYODA, Y. u0026amp; NAKAO, A. (2012). Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovasc Res 94, 144-53.
  • YOSHIDA, A., ASANUMA, H., SASAKI, H., SANADA, S., YAMAZAKI, S., ASANO, Y., SHINOZAKI, Y., MORI, H., SHIMOUCHI, A., SANO, M., ASAKURA, M., MINAMINO, T., TAKASHIMA, S., SUGIMACHI, M., MOCHIZUKI, N. u0026amp; KITAKAZE, M. (2012). H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs. Cardiovasc Drugs Ther 26, 217-26.
  • FUJII, Y., SHIRAI, M., INAMORI, S., SHIMOUCHI, A., SONOBE, T., TSUCHIMOCHI, H., PEARSON, J. T., TAKEWA, Y., TATSUMI, E. u0026amp; TAENAKA, Y. (2013). Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model. Artif Organs 37, 136-41.
  • NAGATANI, K., TAKEUCHI, S., KOBAYASHI, H., OTANI, N., WADA, K., FUJITA, M., NAWASHIRO, H., TACHIBANA, S. SHIMA, K. (2013). The Effect of Hydrogen Gas on a Mouse Bilateral Common Carotid Artery Occlusion. Brain Edema XV Acta Neurochirurgica Supplement
  • T. KASHIWAGI, T. H., S. KABAYAMA, M. TAKAKI, K. TERUYA, Y. KATAKURA, K. OTUBO, S. MORISAWA, S. SHIRAHATA. (2005). Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water. Animal Cell Technology Meets Genomics 2, 257-260.
  • NAKAO, A., KACZOROWSKI, D. J., ZUCKERBRAUN, B. S., LEI, J., FALEO, G., DEGUCHI, K., MCCURRY, K. R., BILLIAR, T. R. u0026amp; KANNO, S. (2008). Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochemical and Biophysical Research Communications 367, 674-9.
  • SATO, Y., KAJIYAMA, S., AMANO, A., KONDO, Y., SASAKI, T., HANDA, S., TAKAHASHI, R., FUKUI, M., HASEGAWA, G., NAKAMURA, N., FUJINAWA, H., MORI, T., OHTA, M., OBAYASHI, H., MARUYAMA, N. u0026amp; ISHIGAMI, A. (2008). Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun 375, 346-350.
  • FU, Y., ITO, M., FUJITA, Y., ITO, M., ICHIHARA, M., MASUDA, A., SUZUKI, Y., MAESAWA, S., KAJITA, Y., HIRAYAMA, M., OHSAWA, I., OHTA, S. u0026amp; OHNO, K. (2009). Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neuroscience Letters 453, 81–85.
  • FUJITA, K., SEIKE, T., YUTSUDO, N., OHNO, M., YAMADA, H., YAMAGUCHI, H., SAKUMI, K., YAMAKAWA, Y., KIDO, M. A., TAKAKI, A., KATAFUCHI, T., TANAKA, Y., NAKABEPPU, Y. u0026amp; NODA, M. (2009). Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One 4, e7247.
  • KUROKI, C., TOKUMARU, O., OGATA, K., KOGA, H. u0026amp; YOKOI, I. (2009). Neuroprotective effects of hydrogen gas on brain in three types of stress models: alpha P-31-NMR study. Neuroscience Research 65, S124-S124.
  • NAGATA, K., NAKASHIMA-KAMIMURA, N., MIKAMI, T., OHSAWA, I. u0026amp; OHTA, S. (2009). Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology 34, 501-508.
  • BARI, F., OLAH, O., NEMETH, I., HUGYECZ, M. u0026amp; DOMOKI, F. (2010). Inhalation of Hydrogen Gas Protects Cerebrovascular Reactivity Against Moderate but Not Severe Perinatal Hypoxic Injury in Newborn Piglets. Stroke 41, E323-E323.
  • DOMOKI, F., OLAH, O., ZIMMERMANN, A., NEMETH, I., TOTH-SZUKI, V., HUGYECZ, M., TEMESVARI, P. u0026amp; BART, F. (2010). Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Pediatric Research 68, 387-392.
  • GU, Y., HUANG, C. S., INOUE, T., YAMASHITA, T., ISHIDA, T., KANG, K. M. u0026amp; NAKAO, A. (2010). Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice. Journal of Clinical Biochemistry and Nutrition 46, 269-276.
  • JI, X., LIU, W., XIE, K., QU, Y., CHAO, X., CHEN, T., ZHOU, J. u0026amp; FEI, Z. (2010). Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Research 1354, 196-205.
  • LI, J., WANG, C., ZHANG, J. H., CAI, J. M., CAO, Y. P. u0026amp; SUN, X. J. (2010). Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res 1328, 152-161.
  • UEDA, Y., NAKAJIMA, A. u0026amp; OIKAWA, T. (2010). Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. Neurochemical Research 35, 1510-1515.
  • YOKOI, I. (2010). Neuroprotective effects of hydrogen gas on brain in three types of stress models: a P-31 NMR and ESR study. Neuroscience Research 68, E320-E320.
  • ECKERMANN, J. M., CHEN, W., JADHAV, V., HSU, F. P., COLOHAN, A. R., TANG, J. u0026amp; ZHANG, J. H. (2011). Hydrogen is neuroprotective against surgically induced brain injury. Medical Gas Research 1, 7.
  • HUGYECZ, M., MRACSKO, E., HERTELENDY, P., FARKAS, E., DOMOKI, F. u0026amp; BARI, F. (2011). Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Research 1404, 31-8.
  • KOBAYASHI, H., OTANI, N., NAWASHIRO, H., SHIMA, K., SUZUKI, S. u0026amp; UENOYAMA, M. (2011). Effects of Hydrogen Gas in a Mouse Cold Induced Brain Injury Model. Journal of Neurotrauma 28, A64-A64.
  • KUROKI, C., TOKUMARU, O., OGATA, K. u0026amp; YOKOI, I. (2011). Neuroprotective effects of hydrogen gas on brain in three types of stress models: A P-31-NMR and ESR study. Neuroscience Research 71, E406-E406.
  • LIU, W., CHEN, O., CHEN, C., WU, B., TANG, J. u0026amp; ZHANG, J. H. (2011). Protective effects of hydrogen on fetal brain injury during maternal hypoxia. Acta Neurochir Suppl 111, 307-11.
  • MANAENKO, A., LEKIC, T., MA, Q., OSTROWSKI, R. P., ZHANG, J. H. u0026amp; TANG, J. (2011). Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage. Acta Neurochir Suppl 111, 179-83.
  • ONO, H., NISHIJIMA, Y., ADACHI, N., TACHIBANA, S., CHITOKU, S., MUKAIHARA, S., SAKAMOTO, M., KUDO, Y., NAKAZAWA, J., KANEKO, K. u0026amp; NAWASHIRO, H. (2011). Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Medical Gas Research 1, 12.
  • SHEN, L., WANG, J., LIU, K., WANG, C., WU, H., SUN, Q., SUN, X. u0026amp; JING, H. (2011). Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochemical Research 36, 1501-11.
  • SUN, Q., CAI, J., ZHOU, J., TAO, H., ZHANG, J. H., ZHANG, W. u0026amp; SUN, X. J. (2011). Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical Care Medicine 39, 765-9.
  • WANG, C., LI, J., LIU, Q., YANG, R., ZHANG, J. H., CAO, Y. P. u0026amp; SUN, X. J. (2011). Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. Neuroscience Letters 491, 127-32.
  • YAN, H., KASHIWAKI, T., HAMASAKI, T., KINJO, T., TERUYA, K., KABAYAMA, S. u0026amp; SHIRAHATA, S. (2011). The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles. BMC Proc 5 Suppl 8, P69.
  • HOU, Z., LUO, W., SUN, X., HAO, S., ZHANG, Y., XU, F., WANG, Z. u0026amp; LIU, B. (2012). Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull 88, 560-5.
  • ITO, M., HIRAYAMA, M., YAMAI, K., GOTO, S., ICHIHARA, M. u0026amp; OHNO, K. (2012). Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. Med Gas Res 2, 15.
  • JI, X., TIAN, Y., XIE, K., LIU, W., QU, Y. u0026amp; FEI, Z. (2012). Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. Journal of Surgical Research 178, e9-16.
  • SPULBER, S., EDOFF, K., HONG, L., MORISAWA, S., SHIRAHATA, S. u0026amp; CECCATELLI, S. (2012). Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice. PLoS One 7, e42078.
  • WANG, W., LI, Y., REN, J., XIA, F., LI, J. u0026amp; ZHANG, Z. (2012). Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurological Research 34, 1007-15.
  • ZHAN, Y., CHEN, C., SUZUKI, H., HU, Q., ZHI, X. u0026amp; ZHANG, J. H. (2012). Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Critical Care Medicine 40, 1291-6.
  • ZHOU, J., CHEN, Y., HUANG, G. Q., LI, J., WU, G. M., LIU, L., BAI, Y. P. u0026amp; WANG, J. (2012). Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. Journal of Surgical Research 178, 390-400.
  • ZHUANG, Z., ZHOU, M. L., YOU, W. C., ZHU, L., MA, C. Y., SUN, X. J. u0026amp; SHI, J. X. (2012). Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci 13, 47.
  • FENG, Y., WANG, R., XU, J., SUN, J., XU, T., GU, Q. u0026amp; WU, X. (2013). Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Curr Eye Res 38, 396-404.
  • MANAENKO, A., LEKIC, T., MA, Q., ZHANG, J. H. u0026amp; TANG, J. (2013). Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Critical Care Medicine 41, 1266-75.
  • YONAMINE, R., SATOH, Y., KODAMA, M., ARAKI, Y. u0026amp; KAZAMA, T. (2013). Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. Anesthesiology 118, 105-13.
 
  • MR TAKAAKI KOMATSU, S. K., AKIRA HAYASHIDA, HIROFUMA NOGAMI, DR KIICHIRO TERUYA, YOSHINORI KATAKURA, KAZUMITI OTSUBO, SHINKATSU MORISAWA, PROF SANETAKA SHIRAHATA. (2001). Suppressive Effect of Electrolyzed-Reduced Water on the Growth of Cancer Cells and Microorganisms. Animal Cell Technology: From Target to Market 1, 220-223.
  • S. SHIRAHATA, S. K., K. KUSUMOTO, M. GOTOH, K. TERUYA, K. OTSUBO, J. S. MORISAWA, H. HAYASHI, K. KATAKURA. (2002). Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Supresses Cell Growth and Regulates Gene Expression of Animal Cells. New Developments and New Applications in Animal Cell Technology, 93-96.
  • KOMATSU, T., KATAKURA, Y., TERUYA, K., OTSUBO, K., MORISAWA, S., u0026amp; u0026amp; SHIRAHATA, S. (2003). Electrolyzed reduced water induces differentiation in K-562 human leukemia cells. Animal cell technology: Basic u0026amp; applied aspects, 387-391.
  • JUN, Y., TERUYA, K., KATAKURA, Y., OTSUBO, K., MORISAWA, S. u0026amp; SHIRAHATA, S. (2004). Suppression of invasion of cancer cells and angiogenesis by electrolyzed reduced water. In Vitro Cellular u0026amp; Developmental Biology-Animal 40, 79A-79A.
  • LEE, K.-J. (2004). Anticancer Effect of Alkaline Reduced Water. J Int Soc Life Inf Sci 22, 302-305.
  • NISHIKAWA, R., TERUYA, K., KATAKURA, Y., OTSUBO, K., MORISAWA, S. u0026amp; SHIRAHATA, S. (2004). Suppression of two-stage cell transformation by electrolyzed reduced water/platinum nanocolloids. In Vitro Cellular u0026amp; Developmental Biology-Animal 40, 79A-79A.
  • NISHIKAWA, R., TERUYA, K., KATAKURA, Y., OSADA, K., HAMASAKI, T., KASHIWAGI, T., KOMATSU, T., LI, Y., YE, J., ICHIKAWA, A., OTSUBO, K., MORISAWA, S., XU, Q. u0026amp; SHIRAHATA, S. (2005). Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation. Cytotechnology 47, 97-105.
  • RYUHEI NISHIKAWA, F. O. A. K. T., YOSHINORI KATAKURA, KAZUMICHI OTSUBO, SHINKATSU MORISAWA, QIANGHUA XU, SANETAKA SHIRAHATA. (2006). Suppression of two-stage cell transformation by electrolyzed reduced water containing platinum nanoparticles. Animal Cell Technology: Basic u0026amp; Applied Aspects 14.
  • SAITOH, Y., OKAYASU, H., XIAO, L., HARATA, Y. u0026amp; MIWA, N. (2008). Neutral pH Hydrogen-Enriched Electrolyzed Water Achieves Tumor-Preferential Clonal Growth Inhibition Over Normal Cells and Tumor Invasion Inhibition Concurrently With Intracellular Oxidant Repression. Oncology Research 17, 247-255.
  • YE, J., LI, Y., HAMASAKI, T., NAKAMICHI, N., KOMATSU, T., KASHIWAGI, T., TERUYA, K., NISHIKAWA, R., KAWAHARA, T., OSADA, K., TOH, K., ABE, M., TIAN, H., KABAYAMA, S., OTSUBO, K., MORISAWA, S., KATAKURA, Y. u0026amp; SHIRAHATA, S. (2008). Inhibitory effect of electrolyzed reduced water on tumor angiogenesis. Biological u0026amp; Pharmaceutical Bulletin 31, 19-26.
  • SAITOH, Y., YOSHIMURA, Y., NAKANO, K. u0026amp; MIWA, N. (2009). Platinum nanocolloid-supplemented hydrogen dissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells. Exp Oncol 31, 156-62.
  • TSAI, C. F., HSU, Y. W., CHEN, W. K., HO, Y. C. u0026amp; LU, F. J. (2009). Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione. Biosci Biotechnol Biochem 73, 280-7.
  • ASADA, R., KAGEYAMA, K., TANAKA, H., MATSUI, H., KIMURA, M., SAITOH, Y. u0026amp; MIWA, N. (2010). Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell death. Oncol Rep 24, 1463-70.
  • KENSUKE NAKANISHI, T. H., TAKURO NAKAMURA,, MASUMI ABE, K. T., YOSHINORI KATAKURA, u0026amp; SHINKATSU MORISAWA, A. S. S. (2010). growth suppression of HL60 and L6 cells by atomic hydrogen.
  • MATSUSHITA, T., KUSAKABE, Y., KITAMURA, A., OKADA, S. u0026amp; MURASE, K. (2011). Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging. Jpn J Radiol 29, 503-12.
  • AKIO KAGAWA, K. K., MASAYUKI MIZUMOTO, YUTAKA TAGAWA, YOICHI MASIKO. (2012). Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells. Materials Science Forum 706, 520-525.
  • KINJO, T., YE, J., YAN, H. X., HAMASAKI, T., NAKANISHI, H., TOH, K., NAKAMICHI, N., KABAYAMA, S., TERUYA, K. u0026amp; SHIRAHATA, S. (2012). Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells. Cytotechnology 64, 357-371.
  • MAKOTO MATSUZAKI, A. K., AIKO MOTOISHI, KUNIHIKO TANAKA, MASATAKA YAMAMOTO, YUTAKA TAGAWA. (2013). Mechanism of Cancer Cell Death Induced by Hydrogen Discharged from Palladium Base Hydrogen Storage Alloy. Materials Science and Chemical Engineering
  • KANG, K.-M., KANG, Y.-N., CHOI, I.-B., GU, Y., KAWAMURA, T., TOYODA, Y. u0026amp; NAKAO, A. (2011). Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research 1, 11.
  • NAKASHIMA-KAMIMURA, N., MORI, T., OHSAWA, I., ASOH, S. u0026amp; OHTA, S. (2009). Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother Pharmacol.
 
 
  • KAWASAKI, H., GUAN, J. J. u0026amp; TAMAMA, K. (2010). Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials. Biochemical and Biophysical Research Communications 397, 608-613.
  • FUJITA, R., TANAKA, Y., SAIHARA, Y., YAMAKITA, M., ANDO, D. u0026amp; KOYAMA, K. (2011). Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle. Journal of Physiological Anthropology 30, 195-201.
  • HANAOKA, T., KAMIMURA, N., YOKOTA, T., TAKAI, S. u0026amp; OHTA, S. (2011). Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide. Medical Gas Research 1, 18.
  • ITOH, T., HAMADA, N., TERAZAWA, R., ITO, M., OHNO, K., ICHIHARA, M. u0026amp; NOZAWA, Y. (2011). Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochemical and Biophysical Research Communications 411, 143-9.
  • KUBOTA, M., SHIMMURA, S., KUBOTA, S., MIYASHITA, H., KATO, N., NODA, K., OZAWA, Y., USUI, T., ISHIDA, S., UMEZAWA, K., KURIHARA, T. u0026amp; TSUBOTA, K. (2011). Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Investigative Ophthalmology and Visual Science 52, 427-33.
  • LEKIC, T., MANAENKO, A., ROLLAND, W., FATHALI, N., PETERSON, M., TANG, J. u0026amp; ZHANG, J. H. (2011). Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats. Acta Neurochir Suppl 111, 237-41.
  • TAKEUCHI, S., WADA, K., NAGATANI, K., OSADA, H., OTANI, N. u0026amp; NAWASHIRO, H. (2012). Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study. Internal Medicine 51, 1309-13.
  • XU, Z., ZHOU, J., CAI, J., ZHU, Z., SUN, X. u0026amp; JIANG, C. (2012). Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema. J Inflamm (Lond) 9, 2.
  • CAI, W. W., ZHANG, M. H., YU, Y. S. u0026amp; CAI, J. H. (2013). Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast. Mol Cell Biochem 373, 1-9.
  • 10. GUO, J. D., LI, L., SHI, Y. M., WANG, H. D. u0026amp; HOU, S. X. (2013). Hydrogen water consumption prevents osteopenia in ovariectomized rats. Br J Pharmacol 168, 1412-20.
  • 11. SUN, Y., SHUANG, F., CHEN, D. M. u0026amp; ZHOU, R. B. (2013). Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int24, 969-78.
 
  • NAKAYAMA, M., KABAYAMA, S., TERAWAKI, H., NAKAYAMA, K., KATO, K., SATO, T. u0026amp; ITO, S. (2007). Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water. Hemodial Int 11, 322-7.
  • YUSUKE OHSAKI1, T. M., 2, YOSHIMI YONEKI1, SATOSHI ENDO1, TAKUMA HOSOYA1, WANJUN ZHU3, MASAAKI NAKAYAMA3 AND SADAYOSHI ITO1. (2008). Electrolyzed water reduces urinary protein excretion in the streptozotocin induced diabetic Dahl salt sensitive rats. The FASEB Journal.
  • CARDINAL, J. S., ZHAN, J., WANG, Y., SUGIMOTO, R., TSUNG, A., MCCURRY, K. R., BILLIAR, T. R. u0026amp; NAKAO, A. (2010). Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney International 77, 101-9.
  • KITAMURA, A., KOBAYASHI, S., MATSUSHITA, T., FUJINAWA, H. u0026amp; MURASE, K. (2010). Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT. British Journal of Radiology 83, 509-514.
  • MATSUSHITA, T., KUSAKABE, Y., KITAMURA, A., OKADA, S. u0026amp; MURASE, K. (2011). Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging. Magn Reson Med Sci 10, 169-76.
  • KATAKURA, M., HASHIMOTO, M., TANABE, Y. u0026amp; SHIDO, O. (2012). Hydrogen-rich water inhibits glucose and alpha,beta -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Medical Gas Research 2, 18.
  • KATO, S., HOKAMA, R., OKAYASU, H., SAITOH, Y., IWAI, K. u0026amp; MIWA, N. (2012). Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity. J Nanosci Nanotechnol 12, 4019-27.
 
  • GHARIB, B., HANNA, S., ABDALLAHI, O. M., LEPIDI, H., GARDETTE, B. u0026amp; DE REGGI, M. (2001). Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III 324, 719-724.
  • ITOH, T., FUJITA, Y., ITO, M., MASUDA, A., OHNO, K., ICHIHARA, M., KOJIMA, T., NOZAWA, Y. u0026amp; ITO, M. (2009). Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun 389, 651-6.
  • KAJIYA, M., SATO, K., SILVA, M. J., OUHARA, K., DO, P. M., SHANMUGAM, K. T. u0026amp; KAWAI, T. (2009). Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun 386, 316-21.
  • PARK, S. K., QI, X. F., SONG, S. B., KIM, D. H., TENG, Y. C., YOON, Y. S., KIM, K. Y., LI, J. H., JIN, D. u0026amp; LEE, K. J. (2009). Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats. Biomed Res 30, 263-9.
  • TSAI, C. F., HSU, Y. W., CHEN, W. K., CHANG, W. H., YEN, C. C., HO, Y. C. u0026amp; LU, F. J. (2009). Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol 47, 2031-6.
  • LIU, Q., SHEN, W. F., SUN, H. Y., FAN, D. F., NAKAO, A., CAI, J. M., YAN, G., ZHOU, W. P., SHEN, R. X., YANG, J. M. u0026amp; SUN, X. J. (2010). Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International 30, 958-968.
  • SHEN, M. H., HE, J. A., CAI, J. M., SUN, Q. A., SUN, X. J. u0026amp; HUO, Z. L. (2010). Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses 75, 235-237.
  • SUN, H., CHEN, L., ZHOU, W., HU, L., LI, L., TU, Q., CHANG, Y., LIU, Q., SUN, X., WU, M. u0026amp; WANG, H. (2011). The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology 54, 471-80.
  • XIANG, L., TAN, J. W., HUANG, L. J., JIA, L., LIU, Y. Q., ZHAO, Y. Q., WANG, K. u0026amp; DONG, J. H. (2012). Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World Journal of Gastroenterology 18, 5197-5204.
  • KOYAMA, Y., TAURA, K., HATANO, E., TANABE, K., YAMAMOTO, G., NAKAMURA, K., YAMANAKA, K., KITAMURA, K., NARITA, M., NAGATA, H., YANAGIDA, A., IIDA, T., IWAISAKO, K., FUJINAWA, H. u0026amp; UEMOTO, S. (2013). Effects of Oral Intake of Hydrogen Water on Liver Fibrogenesis in Mice. Hepatol Res.
  • LIU, G. D., ZHANG, H., WANG, L., HAN, Q., ZHOU, S. F. u0026amp; LIU, P. (2013). Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol 6, 280-5.
  • WANG, W., TIAN, L., LI, Y., WANG, X., XIA, F., LI, L., LI, J. u0026amp; ZHANG, Z. (2013). Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. Journal of Emergency Medicine 44, 107-15.
 
 
  • HUANG, C. S., KAWAMURA, T., LEE, S., TOCHIGI, N., SHIGEMURA, N., BUCHHOLZ, B. M., KLOKE, J. D., BILLIAR, T. R., TOYODA, Y. u0026amp; NAKAO, A. (2010). Hydrogen inhalation ameliorates ventilator-induced lung injury. Critical Care 14, R234.
  • QIU, X. C., JIN, Y. C., SUN, Y., LUO, P. F., FU, J. F., CHEN, B. u0026amp; XIA, Z. F. (2010). [Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation]. Zhonghua Shao Shang Za Zhi 26, 435-8.
  • ZHENG, J., LIU, K., KANG, Z. M., CAI, J. M., LIU, W. W., XU, W. G., LI, R. P., TAO, H. Y., ZHANG, J. H. u0026amp; SUN, X. J. (2010). Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea u0026amp; Hyperbaric Medicine 37, 185-192.
  • FANG, Y., FU, X. J., GU, C., XU, P., WANG, Y., YU, W. R., SUN, Q., SUN, X. J. u0026amp; YAO, M. (2011). Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. Journal of Burn Care and Research 32, e82-91.
  • HUANG, C. S., KAWAMURA, T., PENG, X., TOCHIGI, N., SHIGEMURA, N., BILLIAR, T. R., NAKAO, A. u0026amp; TOYODA, Y. (2011). Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochemical and Biophysical Research Communications 408, 253-8.
  • LIU, S., LIU, K., SUN, Q., LIU, W., XU, W., DENOBLE, P., TAO, H. u0026amp; SUN, X. (2011). Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. Journal of Biomedicine u0026amp; Biotechnology 2011, 305086.
  • QIU, X., LI, H., TANG, H., JIN, Y., LI, W., YUSUN, PINGFENG, SUN, X. u0026amp; XIA, Z. (2011). Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol 11, 2130-7.
  • SUN, Q. A., CAI, J. M., LIU, S. L., LIU, Y., XU, W. G., TAO, H. Y. u0026amp; SUN, X. J. (2011). Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. Journal of Surgical Research 165, E43-E49.
  • TERASAKI, Y., OHSAWA, I., TERASAKI, M., TAKAHASHI, M., KUNUGI, S., DEDONG, K., URUSHIYAMA, H., AMENOMORI, S., KANEKO-TOGASHI, M., KUWAHARA, N., ISHIKAWA, A., KAMIMURA, N., OHTA, S. u0026amp; FUKUDA, Y. (2011). Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. American Journal of Physiology – Lung Cellular and Molecular Physiology 301, L415-26.
  • LIANG, C., LIU, X., LIU, L. u0026amp; HE, D. (2012). [Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao 32, 1211-3.
  • SHI, J., YAO, F., ZHONG, C., PAN, X., YANG, Y. u0026amp; LIN, Q. (2012). Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats. Heart Lung Circ 21, 556-63.
  • XIE, K., YU, Y., HUANG, Y., ZHENG, L., LI, J., CHEN, H., HAN, H., HOU, L., GONG, G. u0026amp; WANG, G. (2012). Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock 37, 548-55.
  • KAWAMURA, T., WAKABAYASHI, N., SHIGEMURA, N., HUANG, C. S., MASUTANI, K., TANAKA, Y., NODA, K., PENG, X., TAKAHASHI, T., BILLIAR, T. R., OKUMURA, M., TOYODA, Y., KENSLER, T. W. u0026amp; NAKAO, A. (2013). Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol 304, L646-56.
  • LIU, W., SHAN, L. P., DONG, X. S., LIU, X. W., MA, T. u0026amp; LIU, Z. (2013). Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol 19, 492-502.
  • XIAO, M., ZHU, T., WANG, T. u0026amp; WEN, F. Q. (2013). Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma. Eur Rev Med Pharmacol Sci 17, 1033-43.
 
  • FUKUDA, K., ASOH, S., ISHIKAWA, M., YAMAMOTO, Y., OHSAWA, I. u0026amp; OHTA, S. (2007). Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun 361, 670-674.
  • CAI, J., KANG, Z., LIU, W. W., LUO, X., QIANG, S., ZHANG, J. H., OHTA, S., SUN, X., XU, W., TAO, H. u0026amp; LI, R. (2008). Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett 441, 167-172.
  • HAYASHIDA, K., SANO, M., KIMURA, K., ENDO, J., KATAYAMA, T., TOKUDOME, S., ONIZUKA, T., YUASA, S., KAWAMURA, A., OGAWA, S. u0026amp; FUKUDA, K. (2008). Inhalation of hydrogen gas protects the heart from ischemic reperfusion injury. Journal of the American College of Cardiology 51, A375-A375.
  • HAYASHIDA, K., SANO, M., OHSAWA, I., SHINMURA, K., TAMAKI, K., KIMURA, K., ENDO, J., KATAYAMA, T., KAWAMURA, A., KOHSAKA, S., MAKINO, S., OHTA, S., OGAWA, S. u0026amp; FUKUDA, K. (2008). Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 373, 30-35.
  • HAYASHIDA, K., SANO, M., OHSAWA, I., SHINMURA, K., TAMAKI, K., KIMURA, K., ENDO, J., OHTA, S., FUKUDA, K. u0026amp; OGAWA, S. (2008). Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Journal of Cardiac Failure 14, S168-S168.
  • KUROKI, C., TOKUMARU, O., OGATA, K. u0026amp; YOKOI, I. (2008). Neuroprotective effects of hydrogen gas on brain in hypoxic stress model and ischemia-reperfusion model: A P-31 NMR study. Neuroscience Research 61, S274-S274.
  • CAI, J. M., KANG, Z. M., LIU, K., LIU, W. W., LI, R. P., ZHANG, J. H., LUO, X. u0026amp; SUN, X. J. (2009). Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res 1256, 129-137.
  • KUROKI, C., TOKUMARU, O., OGATA, K., KOGA, H. u0026amp; YOKOI, I. (2009). Neuroprotective Effects of Hydrogen Gas on Brain in Ischemia-Reperfusion Model: A P-31-Nmr Study. Journal of Physiological Sciences 59, 371-371.
  • MAO, Y. F., ZHENG, X. F., CAI, J. M., YOU, X. M., DENG, X. M., ZHANG, J. H., JIANG, L. u0026amp; SUN, X. J. (2009). Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun 381, 602-5.
  • MATCHETT, G. A., FATHALI, N., HASEGAWA, Y., JADHAV, V., OSTROWSKI, R. P., MARTIN, R. D., DOROTTA, I. R., SUN, X. u0026amp; ZHANG, J. H. (2009). Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Brain Research 1259, 90-7.
  • SUN, Q., KANG, Z. M., CAI, J. M., LIU, W. W., LIU, Y., ZHANG, J. H., DENOBLE, P. J., TAO, H. Y. u0026amp; SUN, X. J. (2009). Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats. Experimental Biology and Medicine 234, 1212-1219.
  • ZHENG, X., MAO, Y., CAI, J., LI, Y., LIU, W., SUN, P., ZHANG, J. H., SUN, X. u0026amp; YUAN, H. (2009). Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res 43, 478-84.
  • KAWAMURA, T., HUANG, C. S., TOCHIGI, N., LEE, S., SHIGEMURA, N., BILLIAR, T. R., OKUMURA, M., NAKAO, A. u0026amp; TOYODA, Y. (2010). Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats. Transplantation 90, 1344-1351
  • NAKAO, A., KACZOROWSKI, D. J., WANG, Y., CARDINAL, J. S., BUCHHOLZ, B. M., SUGIMOTO, R., TOBITA, K., LEE, S., TOYODA, Y., BILLIAR, T. R. u0026amp; MCCURRY, K. R. (2010). Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 29, 544-53.
  • SHINGU, C., KOGA, H., HAGIWARA, S., MATSUMOTO, S., GOTO, K., YOKOI, I. u0026amp; NOGUCHI, T. (2010). Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. Journal of Anesthesia 24, 569-574.
  • CHEN, H., SUN, Y. P., HU, P. F., LIU, W. W., XIANG, H. G., LI, Y., YAN, R. L., SU, N., RUAN, C. P., SUN, X. J. u0026amp; WANG, Q. (2011). The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. Journal of Surgical Research 167, 316-22.
  • ELTZSCHIG, H. K. u0026amp; ECKLE, T. (2011). Ischemia and reperfusion–from mechanism to translation. Nature Medicine 17, 1391-401.
  • HUANG, Y., XIE, K. L., LI, J. P., XU, N., GONG, G., WANG, G. L., YU, Y. H., DONG, H. L. u0026amp; XIONG, L. Z. (2011). Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain Research 1378, 125-136.
  • JI, Q., HUI, K., ZHANG, L., SUN, X., LI, W. u0026amp; DUAN, M. (2011). The effect of hydrogen-rich saline on the brain of rats with transient ischemia. Journal of Surgical Research 168, e95-e101.
  • LIU, Y., LIU, W., SUN, X., LI, R., SUN, Q., CAI, J., KANG, Z., LV, S., ZHANG, J. H. u0026amp; ZHANG, W. (2011). Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model. Medical Gas Research 1, 15.
  • WANG, F., YU, G., LIU, S. Y., LI, J. B., WANG, J. F., BO, L. L., QIAN, L. R., SUN, X. J. u0026amp; DENG, X. M. (2011). Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats. Journal of Surgical Research 167, e339-44.
  • ZHANG, Y., SUN, Q., HE, B., XIAO, J., WANG, Z. u0026amp; SUN, X. (2011). Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. International Journal of Cardiology 148, 91-5.
  • ZHU, W. J., NAKAYAMA, M., MORI, T., NAKAYAMA, K., KATOH, J., MURATA, Y., SATO, T., KABAYAMA, S. u0026amp; ITO, S. (2011). Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Nephrology, Dialysis, Transplantation 26, 2112-8.
  • GE, P., ZHAO, J., LI, S., DING, Y., YANG, F. u0026amp; LUO, Y. (2012). Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. Neurological Research 34, 187-94.
  • JIANG, D., WU, D., ZHANG, Y., XU, B., SUN, X. u0026amp; LI, Z. (2012). Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. J Urol 187, 2249-53.
  • LEE, J. W., KIM, J. I., LEE, Y. A., LEE, D. H., SONG, C. S., CHO, Y. J. u0026amp; HAN, J. S. (2012). Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. Journal of Pediatric Surgery 47, 736-742.
  • LI, H., ZHOU, R., LIU, J., LI, Q., ZHANG, J., MU, J. u0026amp; SUN, X. (2012). Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. Journal of Surgical Research 174, e11-6.
  • LI, J., DONG, Y., CHEN, H., HAN, H., YU, Y., WANG, G., ZENG, Y. u0026amp; XIE, K. (2012). Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. Brain Research 1486, 103-11.
  • NAGATANI, K., TAKEUCHI, S., OTANI, N., WADA, K. u0026amp; NAWASHIRO, H. (2012). Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock 37(6):645-652, 2012 Reply. Shock 38, 444-445.
  • NAGATANI, K., WADA, K., TAKEUCHI, S., KOBAYASHI, H., UOZUMI, Y., OTANI, N., FUJITA, M., TACHIBANA, S. u0026amp; NAWASHIRO, H. (2012). Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock 37, 645-652.
  • ZHANG, J., LIU, C., TAI, M. u0026amp; QU, K. (2012). Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia (Shock 37(6), 645-652, 2012). Shock 38, 444; author reply 444-5.
  • ZHANG, J. Y., LIU, C., TAI, M. H. u0026amp; QU, K. (2012). Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock 37(6):645-652, 2012. Shock 38, 444-444.
  • ZHAO, L., WANG, Y. B., QIN, S. R., MA, X. M., SUN, X. J., WANG, M. L. & ZHONG, R. G. (2013). Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. J Zhejiang Univ Sci B 14, 382-91.
  • ZHOU, L., WANG, X., XUE, W., XIE, K., HUANG, Y., CHEN, H., GONG, G.  & ZENG, Y. (2013). Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. Brain Research 1517, 150-60.
 
  • DARNAUD, C. (1951). [Indications for alkaline mineral water cure in diabetes mellitus]. Toulouse Med 52, 277-84.
  • YOKOYAMA, J.-M. K. A. K. (1997). Effects of alkaline ionized water on spontaneously diabetic GK-rats fed sucrose. Korea. J. of Lab. Anim Sa 13, 187-190.
  • NELSON, D., AVULA, C. P. R., JOLLY, C., DE VIERVILLE, J. u0026amp; FERNANDES, G. (1998). Effect of electrolyzed water intake on lifespan of autoimmune disease prone mice. Faseb Journal 12, A794-A794.
  • M. ODA, K. K., K. TERUYA, T. HARA, T. MAKI, S. KABAYAMA, Y. KATAKURA, K. OTSUBO, S. MORISAWA, H. HAYASHI. (2000). Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes. Animal Cell Technology: Products from Cells, Cells as Products, 425-427.
  • SHIRAHATA, S. (2001). Anti-oxidative water improves diabetes.
  • LI, Y., NISHIMURA, T., TERUYA, K., MAKI, T., KOMATSU, T., HAMASAKI, T., KASHIWAGI, T., KABAYAMA, S., SHIM, S. Y., KATAKURA, Y., OSADA, K., KAWAHARA, T., OTSUBO, K., MORISAWA, S., ISHII, Y., GADEK, Z. u0026amp; SHIRAHATA, S. (2002). Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. Cytotechnology 40, 139-49.
  • CHIASSON, J. L., JOSSE, R. G., GOMIS, R., HANEFELD, M., KARASIK, A. u0026amp; LAAKSO, M. (2003). Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290, 486-94.
  • KIM, H.-W. (2004). Alkaline Reduced Water produced by UMQ showed Anti-cancer and Anti-diabetic effect.
  • SHIRAHATA, S. (2004). The suppressive effect of electrolyzed reduced water on lipid peroxidation.
  • LI, Y.-P., TERUYA, K., KATAKURA, Y., KABAYAMA, S., OTSUBO, K.,MORISAWA, S., ET AL. (2005). Effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic b HIT-T15 cell. Animal cell technology meets genomics, 121-124.
  • ETC..ET.AL, G. Y. (2006). Anti-oxidation Effect and Anti Type 2 Diabetic Effect in Active Hydrogen Water
  • . Medicine and Biology 150, 384-392.
  • JIN, D., RYU, S. H., KIM, H. W., YANG, E. J., LIM, S. J., RYANG, Y. S., CHUNG, C. H., PARK, S. K. u0026amp; LEE, K. J. (2006). Anti-diabetic effect of alkaline-reduced water on OLETF rats. Biosci Biotechnol Biochem 70, 31-7.
  • KIM, M. J. u0026amp; KIM, H. K. (2006). Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. Life Sci 79, 2288-92.
  • N, D. P., SEUNG-KYU ; LEE, YOUNG-MI ; YOON, YANG-SUK ; KIM, DONG-HEUI ; DEUNG, YOUNG-KUN ; LEE, KYU-JAE. (2006). Effect of mineral induced alkaline reduced water on sprague-dawley rats fed on a high fat diet. J. Exp. Biomed. Sci. 12, 1-7.
  • YEUNHWA GU, K. O., TAIGO FUJ, YUKA ITOKAWA, TAKASHI MASUBUCHI, Y. K., TOSHIHIRO MAENAKA,, KWANG-HO CHO7), J.-S. C., TAKENORI YAMASHITA,, YASUYUKI TAKAGI, I.-B. C., KI-MUN KANG,, TAKEO HASEGAWA, T. M., MASAMI OSHIMA u0026amp; IKUKATSU SUZUKI, A. T. I. (2006). Anti Type 2 Diabetic Effect and Anti-oxidation Effect in Active Hydrogen Water Administration KK-Ay Mice. Medicine and Biology 150, 384-392.
  • KIM, M. J., JUNG, K. H., UHM, Y. K., LEEM, K. H. u0026amp; KIM, H. K. (2007). Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. Biol Pharm Bull 30, 234-6.
  • OHSAWA, I., NISHIMAKI, K., YAMAGATA, K., ISHIKAWA, M. u0026amp; OHTA, S. (2008). Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice. Biochem Biophys Res Commun 377, 1195-8.
  • KAWAHITO, S., KITAHATA, H. u0026amp; OSHITA, S. (2009). Problems associated with glucose toxicity: Role of hyperglycemia-induced oxidative stress. World Journal of Gastroenterology 15, 4137-4142.
  • MENGTSAN, C. Y. C. (2009). Effect of alkaline reduced water on erythrocyte oxidative status and plasma lipids of spontaneously hypertensive rats. Taiwanese Journal of Agricultural Chemistry and Food Science 47, 71-72.
  • CHEN, C. H., MANAENKO, A., ZHAN, Y., LIU, W. W., OSTROWKI, R. P., TANG, J. u0026amp; ZHANG, J. H. (2010). Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model. Neuroscience 169, 402-414.
  • MASUMI ABE, S. S., KAZUKO TOH, TAKEKI HAMASAKI, NOBORU NAKAMICHI, KIICHIRO TERUYA, YOSHINORI KATAKURA, SHINKATSU MORISAWA, SANETAKA SHIRAHATA. (2010). Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level. Animal Cell Technology: Basic u0026amp; Applied Aspects 16.
  • HASHIMOTO, M., KATAKURA, M., NABIKA, T., TANABE, Y., HOSSAIN, S., TSUCHIKURA, S. u0026amp; SHIDO, O. (2011). Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model. Medical Gas Research 1, 26.
  • KAMIMURA, N., NISHIMAKI, K., OHSAWA, I. u0026amp; OHTA, S. (2011). Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity.
  • LI, Y., HAMASAKI, T., NAKAMICHI, N., KASHIWAGI, T., KOMATSU, T., YE, J., TERUYA, K., ABE, M., YAN, H., KINJO, T., KABAYAMA, S., KAWAMURA, M. u0026amp; SHIRAHATA, S. (2011). Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology 63, 119-31.
  • NAKAI, Y., SATO, B., USHIAMA, S., OKADA, S., ABE, K. u0026amp; ARAI, S. (2011). Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. Bioscience, Biotechnology, and Biochemistry 75, 774-6.
  • SHIRAHATA, S., HAMASAKI, T., HARAMAKI, K., NAKAMURA, T., ABE, M., YAN, H., KINJO, T., NAKAMICHI, N., KABAYAMA, S. u0026amp; TERUYA, K. (2011). Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles. BMC Proc 5 Suppl 8, P18.
  • SONG, G., TIAN, H., LIU, J., ZHANG, H., SUN, X. u0026amp; QIN, S. (2011). H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells. Biotechnology Letters 33, 1715-22.
  • WANG, Y., JING, L., ZHAO, X. M., HAN, J. J., XIA, Z. L., QIN, S. C., WU, Y. P. u0026amp; SUN, X. J. (2011). Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res 12, 26.
  • YANG, X., GUO, L., SUN, X., CHEN, X. u0026amp; TONG, X. (2011). Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta 32, 681-6.
  • YU, P., WANG, Z., SUN, X., CHEN, X., ZENG, S., CHEN, L. u0026amp; LI, S. (2011). Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications 409, 350-5.
  • EKUNI, D., TOMOFUJI, T., ENDO, Y., KASUYAMA, K., IRIE, K., AZUMA, T., TAMAKI, N., MIZUTANI, S., KOJIMA, A. u0026amp; MORITA, M. (2012). Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol 57, 1615-22.
  • FAN, M., XU, X., HE, X., CHEN, L., QIAN, L., LIU, J., QING, J., CHAO, Z. u0026amp; SUN, X. (2012). Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model. J Urol.
  • KAWAI, D., TAKAKI, A., NAKATSUKA, A., WADA, J., TAMAKI, N., YASUNAKA, T., KOIKE, K., TSUZAKI, R., MATSUMOTO, K., MIYAKE, Y., SHIRAHA, H., MORITA, M., MAKINO, H. u0026amp; YAMAMOTO, K. (2012). Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology 56, 912-21.
  • NISHIOKA, S., YOSHIOKA, T., OHKITA, M., MATSUMURA, Y., ISHIZAKA, N., OKADA, Y. u0026amp; HAYASHI, T. (2012). Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia in mice. European Heart Journal 33, 794-794.
  • WANG, Q. J., ZHA, X. J., KANG, Z. M., XU, M. J., HUANG, Q. u0026amp; ZOU, D. J. (2012). Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J (Engl) 125, 1633-7.
  • YU, Y. S. u0026amp; ZHENG, H. (2012). Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem 365, 233-42.
  • ZHENG, H. u0026amp; YU, Y. S. (2012). Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochemical Pharmacology 83, 1269-77.
  • ZONG, C., SONG, G., YAO, S., LI, L., YU, Y., FENG, L., GUO, S., LUO, T. u0026amp; QIN, S. (2012). Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism 61, 794-800.
  • AMITANI, H., ASAKAWA, A., CHENG, K. C., AMITANI, M., KAIMOTO, K., NAKANO, M., USHIKAI, M., LI, Y. X., TSAI, M. L., LI, J. B., TERASHI, M., CHAOLU, H., KAMIMURA, R. u0026amp; INUI, A. (2013). Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One 8.
  • IIO, A., ITO, M., ITOH, T., TERAZAWA, R., FUJITA, Y., NOZAWA, Y., OHSAWA, I. u0026amp; OHNO, K. (2013). Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. Medical Gas Research 3, 6.
  • JIANG, H., YU, P., QIAN, D. H., QIN, Z. X., SUN, X. J., YU, J. u0026amp; HUANG, L. (2013). Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis. Int J Mol Med 31, 1381-7.
 
  • NAITO, Y., TAKAGI, T., UCHIYAMA, K., TOMATSURI, N., MATSUYAMA, K., FUJII, T., YAGI, N., YOSHIDA, N. u0026amp; YOSHIKAWA, T. (2002). Chronic administration with electrolyzed alkaline water inhibits aspirin-induced gastric mucosal injury in rats through the inhibition of tumor necrosis factor-alpha expression. Journal of Clinical Biochemistry and Nutrition 32, 69-81.
  • VOROBJEVA, N. V. (2005). Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water. Med Hypotheses 64, 543-6.
  • BUCHHOLZ, B. M., KACZOROWSKI, D. J., SUGIMOTO, R., YANG, R., WANG, Y., BILLIAR, T. R., MCCURRY, K. R., BAUER, A. J. u0026amp; NAKAO, A. (2008). Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant 8, 2015-2024.
  • JIN, D. K., DONG-HEUI ; TENG, YUNG-CHIEN ; XUFENG, QI ; LEE, KYU-JAE (2008). The Effect of Mineral-induced Alkaline Reduced Water on the DSS-induced Acute inflammatory Bowel Disease Mouse Model. Korean Journal of Microscopy 38, 81-87.
  • KAJIYA, M., SILVA, M. J., SATO, K., OUHARA, K. u0026amp; KAWAI, T. (2009). Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun, in press.
  • XIE, K. L., HOU, L. C., WANG, G. L. u0026amp; XIONG, L. Z. (2010). [Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice]. Zhejiang Da Xue Xue Bao Yi Xue Ban 39, 454-7.
  • XIE, K. L., YU, Y. H., PEI, Y. P., HOU, L. C., CHEN, S. Y., XIONG, L. Z. u0026amp; WANG, G. L. (2010). Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock 34, 90-97.
  • BUCHHOLZ, B. M., MASUTANI, K., KAWAMURA, T., PENG, X., TOYODA, Y., BILLIAR, T. R., BAUER, A. J. u0026amp; NAKAO, A. (2011). Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation 92, 985-92.
  • YICHAO JIN, X. Q., YU SUN, GUOFENG HUANG, XUEJUN SUN AND ZHAO‐FAN XIA. (2011). Hydrogen May Be Used as a Treatment for Stress-Induced Gastric Ulceration. Med. Hypotheses Res 7, 43-47.
  • LIU, X., CHEN, Z., MAO, N. u0026amp; XIE, Y. (2012). The protective of hydrogen on stress-induced gastric ulceration. Int Immunopharmacol 13, 197-203.
  • XIE, K., FU, W., XING, W., LI, A., CHEN, H., HAN, H., YU, Y. u0026amp; WANG, G. (2012). Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock 38, 656-63.
  • XIE, K., YU, Y., HOU, L., CHEN, H., HAN, H., XIONG, L. u0026amp; WANG, G. (2012). Nrf2 is critical in the protective role of hydrogen gas against murine polymicrobial sepsis. British Journal of Anaesthesia 108, 538-539.
  • HE, J., XIONG, S., ZHANG, J., WANG, J., SUN, A., MEI, X., SUN, X., ZHANG, C. u0026amp; WANG, Q. (2013). Protective effects of hydrogen-rich saline on ulcerative colitis rat model. Journal of Surgical Research.
  • LI, G. M., JI, M. H., SUN, X. J., ZENG, Q. T., TIAN, M., FAN, Y. X., LI, W. Y., LI, N. u0026amp; YANG, J. J. (2013). Effects of hydrogen-rich saline treatment on polymicrobial sepsis. Journal of Surgical Research 181, 279-86.
 
  • QIAN, L. R., CAO, F., CUI, J. G., HUANG, Y. C., ZHOU, X. J., LIU, S. L. u0026amp; CAI, J. M. (2010). Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res 44, 275-282.
  • QIAN, L. R., LI, B. L., CAO, F., HUANG, Y. C., LIU, S. L., CAI, J. M. u0026amp; GAO, F. (2010). Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology u0026amp; Radiation Protection 25, 23-29.
  • YOON, K. S., HUANG, X. Z., YOON, Y. S., KIM, S. K., SONG, S. B., CHANG, B. S., KIM, D. H. u0026amp; LEE, K. J. (2011). Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biological and Pharmaceutical Bulletin 34, 1671-7.
  • ZHAO, L., ZHOU, C., ZHANG, J., GAO, F., LI, B., CHUAI, Y., LIU, C. u0026amp; CAI, J. (2011). Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice. International Journal of Biological Sciences 7, 297-300.
  • KATO, S., SAITOH, Y., IWAI, K. u0026amp; MIWA, N. (2012). Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B 106, 24-33.
  • WEI, L., GE, L., QIN, S., SHI, Y., DU, C., DU, H., LIU, L., YU, Y. u0026amp; SUN, X. (2012). Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig. Experimental Eye Research 94, 117-27.
  • YANG, Y., LI, B., LIU, C., CHUAI, Y., LEI, J., GAO, F., CUI, J., SUN, D., CHENG, Y., ZHOU, C. u0026amp; CAI, J. (2012). Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit 18, BR144-8.
  • IGNACIO, R. M., YOON, Y. S., SAJO, M. E. J., KIM, C. S., KIM, D. H., KIM, S. K. u0026amp; LEE, K. J. (2013). The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Molecular u0026amp; Cellular Toxicology 9, 15-21.
  • JIANG, Z., XU, B., YANG, M., LI, Z., ZHANG, Y. u0026amp; JIANG, D. (2013). Protection by hydrogen against gamma ray-induced testicular damage in rats. Basic Clin Pharmacol Toxicol 112, 186-91.

 

  • CHEN, C. W., CHEN, Q. B., MAO, Y. F., XU, S. M., XIA, C. Y., SHI, X. Y., ZHANG, J. H., YUAN, H. B. u0026amp; SUN, X. J. (2010). Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats. Neurochemical Research 35, 1111-1118.
  • CHEN, H., SUN, Y. P., LI, Y., LIU, W. W., XIANG, H. G., FAN, L. Y., SUN, Q., XU, X. Y., CAI, J. M., RUAN, C. P., SU, N., YAN, R. L., SUN, X. J. u0026amp; WANG, Q. (2010). Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun 393, 308-313.
  • REN, J., LUO, Z., TIAN, F., WANG, Q., LI, K. u0026amp; WANG, C. (2012). Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg 72, 1555-61.
  • ZHANG, D. Q. u0026amp; ZHU, J. H. (2012). [Experimental studies of effects of hydrogen-rich saline in rats with severe acute pancreatitis]. Zhonghua Yi Xue Za Zhi 92, 2436-40.
 

 

  • (1973). Navy Studies Hydrogen as Breathing Gas. Design News 28, 22-22.
  • WATANABE, T., PAN, I., FUKUDA, Y., MURASUGI, E., KAMATA, H. u0026amp; UWATOKO, K. (1998). Influences of alkaline ionized water on milk yield, body weight of offspring and perinatal dam in rats. J Toxicol Sci 23, 365-71.
  • WATANABE, T., KAMATA, H., FUKUDA, Y., MURASUGI, E., SATO, T., UWATOKO, K. u0026amp; PAN, I. J. (2000). Influences of alkaline ionized water on milk electrolyte concentrations in maternal rats. J Toxicol Sci 25, 417-22.
  • MERNE, M. E., SYRJANEN, K. J. u0026amp; SYRJANEN, S. M. (2001). Systemic and local effects of long-term exposure to alkaline drinking water in rats. Int J Exp Pathol 82, 213-9.
  • HAN-SUK JUNG1, D.-H. K., YANG-SUK YOON, YUNG-CHIEN TENG, u0026amp; LEE, B.-S. C. A. K.-J. (2008). Evaluate of Electrochemical Characteristics in Electrolyzed Reduced Water
  • . Korean J. Microscopy 38, 321-324.
  • LEE, K. J., JIN, D., CHANG, B. S., TENG, Y. C. u0026amp; KIM, D. H. (2009). The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice. Biol Pharm Bull 32, 456-62.
  • SAITOH, Y., HARATA, Y., MIZUHASHI, F., NAKAJIMA, M. u0026amp; MIWA, N. (2010). Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity. Toxicology and Industrial Health 26, 203-216.
  • NI, X. X., CAI, Z. Y., FAN, D. F., LIU, Y., ZHANG, R. J., LIU, S. L., KANG, Z. M., LIU, K., LI, R. P., SUN, X. J. u0026amp; XU, W. G. (2011). Protective effect of hydrogen-rich saline on decompression sickness in rats. Aviation Space and Environmental Medicine 82, 604-9.
  • YOON, Y. S., KIM, D. H., KIM, S. K., SONG, S. B., UH, Y., JIN, D., QI, X. F., TENG, Y. C. u0026amp; LEE, K. J. (2011). The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice. Food and Chemical Toxicology 49, 1814-9.
 
  • KUMON, K. (1997). What Is Functional Water? Artificial Organs 21, 2-4.
  • OKOUCHI, S., SUZUKI, M., SUGANO, K., KAGAMIMORI, S. u0026amp; IKEDA, S. (2002). Water desirable for the human body in terms of oxidation-reduction potential (ORP) to pH relationship. Journal of Food Science 67, 1594-1598.
  • SHIRAHATA, S. A. N. E. T. A. K. A. (2002). Reduced water for prevention of diseases. Animal Cell Technology: Basic and Applied Aspects 12, 25-30.
  • BALL, J. (2007). Recently published papers: More about EGDT, experimental therapies and some inconvenient truths. Critical Care 11.
  • WOOD, K. C. u0026amp; GLADWIN, M. T. (2007). The hydrogen highway to reperfusion therapy. Nat Med 13, 673-674.
  • OHTA, S. (2008). [Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept]. Nihon Ronen Igakkai Zasshi 45, 355-62.
  • Jun, X.S. and H. Zhang, Hydrogen-an endogenous antioxidant in the body. Academic Journal of Second Military Medical University, 2008. 28(3): p. 233-235.
  • MILTON, S. L. (2009). Hydrogen Saline a Real Gas. Journal of Experimental Biology 212, v-vi.
  • NAKAO, A., SUGIMOTO, R., BILLIAR, T. R. u0026amp; MCCURRY, K. R. (2009). Therapeutic Antioxidant Medical Gas. Journal of Clinical Biochemistry and Nutrition 44, 1-13.
  • GEORGE, J. F. u0026amp; AGARWAL, A. (2010). Hydrogen: another gas with therapeutic potential. Kidney International 77, 85-87.
  • GONCHARUK, V. V., BAGRII, V. A., MEL’NIK, L. A., CHEBOTAREVA, R. D. u0026amp; BASHTAN, S. Y. (2010). The use of redox potential in water treatment processes. Journal of Water Chemistry and Technology 32, 1-9.
  • HONG, Y., CHEN, S. u0026amp; ZHANG, J. M. (2010). Hydrogen as a selective antioxidant: a review of clinical and experimental studies. Journal of International Medical Research 38, 1893-903.
  • HUANG, C. S., KAWAMURA, T., TOYODA, Y. u0026amp; NAKAO, A. (2010). Recent advances in hydrogen research as a therapeutic medical gas. Free Radical Research 44, 971-982.
  • LIU, C., CUI, J. G., SUN, Q. u0026amp; CAI, J. M. (2010). Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical Hypotheses 74, 145-146.
  • QIAN, L. R., LI, B. L., CAI, J. M. u0026amp; GAO, F. (2010). The Hypothesis of an Effective Safe and Novel Radioprotective Agent Hydrogen-rich Solution. West Indian Medical Journal 59, 122-124.
  • CHUAI, Y., ZHAO, L., NI, J., SUN, D., CUI, J., LI, B., QIAN, L., GAO, F. u0026amp; CAI, J. (2011). A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution. Medical Science Monitor 17, HY1-4.
  • JUN CHEN, B. Z., MINGCHAO LI, TAO QI, ZHENG CHEN, XUEJUN SUN, XIAO CHEN (2011). Hydrogen therapy may be a promising, safe and effective treatment for diabetic erectile dysfunction: a hypothesis. Alternative Medicine Studies.
  • OHTA, S. (2011). Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des 17, 2241-52.
  • OHTA, S., NAKAO, A. u0026amp; OHNO, K. (2011). The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research Medical Gas Research 1, 10.
  • OHTA, S., NAKAO, A. u0026amp; OHNO, K. (2011). The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research. Med Gas Res 1, 10.
  • SCHOENFELD, M. P., ANSARI, R. R., ZAKRAJSEK, J. F., BILLIAR, T. R., TOYODA, Y., WINK, D. A. u0026amp; NAKAO, A. (2011). Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. Medical Hypotheses 76, 117-8.
  • YONGCHUN SHEN, T. Y., TAO WANG, FUQIANG WEN. (2011). Hydrogen gas: a novel antioxidant for chronic obstructive pulmonary disease. Journal of Medical Colleges of PLA 26, 94-97.
  • GHANIZADEH, A. (2012). Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism. European Review for Medical and Pharmacological Sciences 16, 1313-4.
  • GHANIZADEH, A. (2012). Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production. Medical Gas Research 2, 19.
  • L, D. u0026amp; WANG, W. C. (2012). Can hydrogen retard the progression of osteoarthritis? African Journal of Pharmacy and Pharmacology 6, 352-354.
  • OHNO, K., ITO, M. u0026amp; ICHIHARA, M. (2012). Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxidative Medicine and Cellular Longevity 2012, 353152.
  • OHTA, S. (2012). Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases. Biochimica et Biophysica Acta 1820, 586-94.
  • OSTOJIC, S. M. (2012). Serum alkalinization and hydrogen-rich water in healthy men. Mayo Clin Proc 87, 501-2.
  • RHEEM, K. E., LIM, Y. R., LEE, B. S., LEE, S. K., SEONG, K. M., HYUN, D. H. u0026amp; MIN, K. J. (2012). Does alkaline-reduced hexagonal water delay the aging process in Drosophila? Geriatr Gerontol Int 12, 151-4.
  • SCHOENFELD, M. P., ANSARI, R. R., NAKAO, A. u0026amp; WINK, D. (2012). A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures. Medical Gas Research 2, 8.
  • SHI, P. u0026amp; SUN, W. (2012). A hypothesis on chemical mechanism of the effect of hydrogen. Med Gas Res 2, 17.
  • SHIRAHATA, S., HAMASAKI, T. u0026amp; TERUYA, K. (2012). Advanced research on the health benefit of reduced water. Trends in Food Science u0026amp; Technology 23, 124-131.
  • SHULIN LIU, X. S. A. H. T. (2012). Hydrogen from a biologically inert gas to a unique antioxidant.
  • SIMON, A. R. (2012). Hydrogen-supplemented drinking water, just soda or an elixir of life? Transplant International 25, 1211-1212.
  • ZHANG, J. Y., LIU, C., ZHOU, L., QU, K., WANG, R. T., TAI, M. H., LEI, J. C. W. L., WU, Q. F. u0026amp; WANG, Z. X. (2012). A Review of Hydrogen as a New Medical Therapy. Hepato-Gastroenterology 59, 1026-1032.
  • DIXON, B. J., TANG, J. u0026amp; ZHANG, J. H. (2013). The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance. Med Gas Res 3, 10.
  • GHANIZADEH, A. u0026amp; BERK, M. (2013). Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia. Med Gas Res 3, 11.
  • QU, J. u0026amp; LU, X. (2013). Hydrogen: A promising novel treatment for hepatic encephalopathy? Free Radic Biol Med.
 
Vi har samlat ännu mer forskningsrapporter om detta vatten här och valt att behålla dessa ursprungstexter på engelska.  
Livsvattens joniserade och funktionella vatten har olika namn i forskning och media:
Forskningsuttryck:
  • Electrolysis Reduced Water (ERW)
  • Electrolyzed Anode Water (EAW)
  • Alkaline or Acid Reduced Water
  • Electrolyzed Ionized Water
  • Alkaline Antioxidant Water

Marknadsföringstermer

  • Ionized Water
  • Water Ionizer
  • Alkaline Antioxidant Water
  • Structured Water
  • Miracle Water/Kangen Water

Använd din mus för att navigera tillbaks till huvudmenyn.

Forskning på joniserat basiskt vatten

(Alkaline Electrolyzed Reduced Water Research )

  • Inhibitory effect of electrolyzed reduced water on tumor angiogenesis
  • Preservative effect of electrolyzed reduced water on pancreatic β-cell mass in diabetic mice
  • Anti cancer effect of alkaline reduced water
  • Electrolyzed-reduced water scavenges active oxygen u0026amp; protects DNA from oxidative damage.
  • Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein.
  • The mechanism of the enhanced antioxidant effects of reduced water produced by electrolysis.
  • Use of ionized water in hypochlorhydria, achlorhydria, reduction of high blood pressure
  • Use of ionized water for gynecological conditions
  • Clinical improvements obtained from the uptake of Ionized Water
  • Alkaline ionized water for abdominal complaints: Placebo controlled double blind tests
  • Physiological effects of alkaline ionized water: intestinal fermentation
  • Effects of calcium alkaline ionized water on formation and maintenance of osseous tissues
  • Reduced water for prevention of disease
  • Use of Ionized water in heart disease and toxins
  • Use of Ionized water in skin disease.
  • Use of Ionized water in allergies.
  • Use of Ionized water in diabetes treatment
  • Use of Ionized water in treating Acidosis
  • Environmental electrochemistry of water
  • Fluid replacement promotes optimal physical performance

Forskning på joniserat surt vatten

(Acidic Electrolyzed Reduced Water Research )

  • Anti microbial interventions to reduce Salmonella species on poultry
  • Treatment of Escherichia coli inoculated alfalfa sprouts with electrolyzed oxidizing water
  • Inactivation of E. coli u0026amp; Listeria on plastic kitchen cutting boards by electrolyzed oxidizing water.
  • The bactericidal effects of electrolyzed oxidizing water on bacterial strains in hospital infections
  • Effect of electrolyzed water on wound healing
  • Effect of electrolyzed oxidizing water on excised burn-wounds in rats
  • Decomposition of ethylene, a flower-senescence hormone, with electrolyzed anode water.

Alkaline Electrolyzed Reduced Water – Ionized Water

Inhibitory effect of electrolyzed reduced water on tumor angiogenesis

Biological & Pharmaceutical Bulletin. 2008 Jan;31(1):19-26

Ye J, Li Y, Hamasaki T, Nakamichi N, Komatsu T, Kashiwagi T, Teruya K, Nishikawa R, Kawahara T, Osada K, Toh K, Abe M, Tian H, Kabayama S, Otsubo K, Morisawa S, Katakura Y, Shirahata S.

Graduate School of Systems Life Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8581, JapanVascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. Tumor cells are exposed to higher oxidative stress compared to normal cells. Numerous reports have demonstrated that the intracellular redox (oxidation/reduction, ORP) state is closely associated with the pattern of VEGF expression. Electrolyzed reduced water (ERW) produced near the cathode during the electrolysis of water scavenged intracellular H(2)O(2) and decreased the release of H(2)O(2) from a human lung adenocarcinoma cell line, A549, and down-regulated both VEGF transcription and protein secretion in a time-dependent manner. To investigate the signal transduction pathway involved in regulating VEGF expression, mitogen-activated kinase (MAPK) specific inhibitors, SB203580 (p38 MAPK inhibitor), PD98059 (ERK1/2 inhibitor) and JNKi (c-Jun N-terminal protein kinase inhibitor) were applied. The results showed that only PD98059 blocks VEGF expression, suggesting an important role for ERK1/2 in regulating VEGF expression in A549 cells. As well, ERW inhibited the activation of extracellular signal-regulated kinase (ERK) in a time-dependent manner. Co-culture experiments to analyze in vitro tubule formation assay revealed that A549 cell-derived conditioned medium significantly stimulated the formation of vascular tubules in all analyzed parameters; tubule total area, tubule junction, number of tubules, and total tubule length. ERW counteracted the effect of A549 cell-conditioned medium and decreased total tube length (p<0.01). The present study demonstrated that ERW down-regulated VEGF gene transcription and protein secretion through inactivation of ERK.Related Research:

Levels of Soluble Vascular Endothelial Growth Factor (VEGF) Receptor 1 in Astrocytic Tumors and Its Relation to Malignancy, Vascularity, and VEGF-A

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Preservative Effect of Electrolyzed Reduced Water on Pancreatic β-Cell Mass in Diabetic db/db Mice

Biological & Pharmaceutical Bulletin 2007 Feb;30(2):234-6Mi-Ja Kim1,2, Kyung Hee Jung,3 Yoon Kyung Uhm,3 Kang-Hyun Leem,4 and Hye Kyung Kim,51) Department of Obesity Management, Graduate School of Obesity Science, Dongduk Women’s University

2) Imagine Obesity Institute, 117 Purynsol Mun Wa Gyun, Kyung Hee University

3) Department of Pharmacology, College of Medicine, Kyung Hee University

4) College of Korean Medicine, Semyung University

5) Department of Food and Biotechnology, Hanseo UniversityOxidative stress is produced under diabetic conditions and involved in progression of pancreatic β-cell dysfunction. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in genetically diabetic mouse strain C57BL/6J-db/db (db/db). ERW with ROS scavenging ability reduced the blood glucose concentration, increased blood insulin level, improved glucose tolerance and preserved β-cell mass in db/db mice. The present data suggest that ERW may protects β-cell damage and would be useful for antidiabetic agent.Related Research:

Involvement of Oxidative Stress and the JNK Pathway in Glucose Toxicity

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Anti Cancer Effect of Alkaline Reduced Water

By the Department of Parasitology, Institute of Basic Medical Sciences, Department of Microbiology, Department of Biochemistry, Wonju College of Medicine , Yonsei University Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University .

Certain minerals can produce alkaline reduced water with high pH and low oxidation-reduction potential (ORP) when dissolved in water. Alkaline reduced water showed significant anticancer effect. When B16 melanoma cells were inoculated subcutaneous and intra-peritoneally, C56BL/6 mice fed with alkaline reduced water showed tumor growth delay and the survival span was significantly lengthened. Alkaline reduced water also showed the inhibition of metastasis by reducing the numbers of B16 melanoma colonies when injected through tail vein. The amount of reactive oxygen species (ROS) was very reduced when fed with alkaline reduced water except for spleen, which is a major organ for immunity. Even for normal mice, alkaline reduced water intake invoked systemic cytokines, such as, Th1 (IFN- g, IL-12) and Th2 (IL-4, IL-5), suggesting strong immuno-modulation effect. Both ROS scavenging effect and immuno-modulation effect might be responsible for anticancer effect of alkaline reduced water. Continue reading the full study

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Adequate fluid replacement helps maintain hydration and, promotes the health, safety, and optimal physical performance of individuals participating in regular physical activity.

Med Sci Sports Exercise

1996 Jan;28(1):i-vii.American College of Sports Medicine position stand. Exercise and fluid replacement. Convertino VA, Armstrong LE, Coyle EF, Mack GW, Sawka MN, Senay LC Jr, Sherman WM.It is the position of the American College of Sports Medicine that adequate fluid replacement helps maintain hydration and, therefore, promotes the health, safety, and optimal physical performance of individuals participating in regular physical activity. This position statement is based on a comprehensive review and interpretation of scientific literature concerning the influence of fluid replacement on exercise performance and the risk of thermal injury associated with dehydration and hyperthermia. Based on available evidence, the American College of Sports Medicine makes the following general recommendations on the amount and composition of fluid that should be ingested in preparation for, during, and after exercise or athletic competition: 1) It is recommended that individuals consume a nutritionally balanced diet and drink adequate fluids during the 24-hr period before an event, especially during the period that includes the meal prior to exercise, to promote proper hydration before exercise or competition. 2) It is recommended that individuals drink about 500 ml (about 17 ounces) of fluid about 2 h before exercise to promote adequate hydration and allow time for excretion of excess ingested water. 3) During exercise, athletes should start drinking early and at regular intervals in an attempt to consume fluids at a rate sufficient to replace all the water lost through sweating (i.e., body weight loss), or consume the maximal amount that can be tolerated. 4) It is recommended that ingested fluids be cooler than ambient temperature [between 15 degrees and 22 degrees C (59 degrees and 72 degrees F])] and flavored to enhance palatability and promote fluid replacement. Fluids should be readily available and served in containers that allow adequate volumes to be ingested with ease and with minimal interruption of exercise. 5) Addition of proper amounts of carbohydrates and/or electrolytes to a fluid replacement solution is recommended for exercise events of duration greater than 1 h since it does not significantly impair water delivery to the body and may enhance performance. During exercise lasting less than 1 h, there is little evidence of physiological or physical performance differences between consuming a carbohydrate-electrolyte drink and plain water. 6) During intense exercise lasting longer than 1 h, it is recommended that carbohydrates be ingested at a rate of 30-60 g.h(-1) to maintain oxidation of carbohydrates and delay fatigue. This rate of carbohydrate intake can be achieved without compromising fluid delivery by drinking 600-1200 ml.h(-1) of solutions containing 4%-8% carbohydrates (g.100 ml(-1)). The carbohydrates can be sugars (glucose or sucrose) or starch (e.g., maltodextrin). 7) Inclusion of sodium (0.5-0.7 g.1(-1) of water) in the rehydration solution ingested during exercise lasting longer than 1 h is recommended since it may be advantageous in enhancing palatability, promoting fluid retention, and possibly preventing hyponatremia in certain individuals who drink excessive quantities of fluid. There is little physiological basis for the presence of sodium in n oral rehydration solution for enhancing intestinal water absorption as long as sodium is sufficiently available from the previous meal.

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage.

Biochem Biophys Res Commun.
1997 May 8;234(1):269-74.

Shirahata S, Kabayama S, Nakano M, Miura T, Kusumoto K, Gotoh M, Hayashi H, Otsubo K, Morisawa S, Katakura Y.

Institute of Cellular Regulation Technology, Graduate School of Genetic Resources Technology, Kyushu University, Fukuoka, Japan. [email protected] Active oxygen species or free radicals are considered to cause extensive oxidative damage to biological macromolecules, which brings about a variety of diseases as well as aging. The ideal scavenger for active oxygen should be ‘active hydrogen’. ‘Active hydrogen’ can be produced in reduced water near the cathode during electrolysis of water. Reduced water exhibits high pH, low dissolved oxygen (DO), extremely high dissolved molecular hydrogen (DH), and extremely negative redox potential (RP) values. Strongly electrolyzed-reduced water, as well as ascorbic acid, (+)-catechin and tannic acid, completely scavenged O.-2 produced by the hypoxanthine-xanthine oxidase (HX-XOD) system in sodium phosphate buffer (pH 7.0). The superoxide dismutase (SOD)-like activity of reduced water is stable at 4 degrees C for over a month and was not lost even after neutralization, repeated freezing and melting, deflation with sonication, vigorous mixing, boiling, repeated filtration, or closed autoclaving, but was lost by opened autoclaving or by closed autoclaving in the presence of tungsten trioxide which efficiently adsorbs active atomic hydrogen. Water bubbled with hydrogen gas exhibited low DO, extremely high DH and extremely low RP values, as does reduced water, but it has no SOD-like activity. These results suggest that the SOD-like activity of reduced water is not due to the dissolved molecular hydrogen but due to the dissolved atomic hydrogen (active hydrogen). Although SOD accumulated H2O2 when added to the HX-XOD system, reduced water decreased the amount of H2O2 produced by XOD. Reduced water, as well as catalase and ascorbic acid, could directly scavenge H2O2. Reduced water suppresses single-strand breakage of DNA b active oxygen species produced by the Cu(II)-catalyzed oxidation of ascorbic acid in a dose-dependent manner, suggesting that reduced water can scavenge not only O2.- and H2O2, but also 1O2 and .OH. PMID: 9169001 [PubMed – indexed for MEDLINE]

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein.

Appl Biochem Biotechnol.

2006 Nov;135(2):133-44.Lee MY, Kim YK, Ryoo KK, Lee YB, Park EJ. Department of Genetic Engineering, Soonchunhyang University, Asan, Chungnam 336-600, Korea.The generation of reactive oxygen species is thought to cause extensive oxidative damage to various biomolecules such as DNA, RNA, and protein. In this study, the preventive, suppressive, and protective effects of in vitro supplementation with electrolyzed-reduced water on H2O2-induced DNA damage in human lymphocytes were examined using a comet assay. Pre-treatment, co-treatment, and post-treatment with electrolyzed-reduced water enhanced human lymphocyte resistance to the DNA strand breaks induced by H2O2 in vitro. Moreover, electrolyzed-reduced water was much more effective than diethylpyrocarbonate-treated water in preventing total RNA degradation at 4 and 25 degrees C. In addition, electrolyzed-reduced water completely prevented the oxidative cleavage of horseradish peroxidase, as determined using sodium dodecyl sulfate-polyacrylamide gels. Enhancement of the antioxidant activity of ascorbic acid dissolved in electrolyzed-reduced water was about threefold that of ascorbic acid dissolved in nonelectrolyzed deionized water, as measured by a xanthine-xanthine oxidase superoxide scavenging assay system, suggesting an inhibitory effect of electrolyzedreduced water on the oxidation of ascorbic acid.PMID: 17159237 [PubMed – indexed for MEDLINE]

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

The mechanism of the enhanced antioxidant effects against superoxide anion radicals of reduced water produced by electrolysis.

Biophys Chem. 2004
Jan 1;107(1):71-82.

Hanaoka K, Sun D, Lawrence R, Kamitani Y, Fernandes G.

Bio-REDOX Laboratory Inc. 1187-4, Oaza-Ueda, Ueda-shi, Nagano-ken 386-0001, Japan. [email protected]

We reported that reduced water produced by electrolysis enhanced the antioxidant effects of proton donors such as ascorbic acid (AsA) in a previous paper. We also demonstrated that reduced water produced by electrolysis of 2 mM NaCl solutions did not show antioxidant effects by itself. We reasoned that the enhancement of antioxidant effects may be due to the increase of the ionic product of water as solvent. The ionic product of water (pKw) was estimated by measurements of pH and by a neutralization titration method. As an indicator of oxidative damage, Reactive Oxygen Species- (ROS) mediated DNA strand breaks were measured by the conversion of supercoiled phiX-174 RF I double-strand DNA to open and linear forms. Reduced water had a tendency to suppress single-strand breakage of DNA induced by reactive oxygen species produced by H2O2/Cu (II) and HQ/Cu (II) systems. The enhancement of superoxide anion radical dismutation activity can be explained by changes in the ionic product of water in the reduced water.

PMID: 14871602 [PubMed]

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Use of Ionized water in hypochlorhydria or achlorhydria

Prof. Kuninaka Hironage, Head of Kuninaka Hospital “Too many fats in the diets, which lead to the deposition of cholesterol on the blood vessels, which in turn constrict the blood flow, cause most illnesses such as high blood pressure. In accordance with the theory of Professor Gato of Kyushu University on Vitamin K (because vitamin K enables the blood calcium to increase ), or the consumption of more antioxidant water, the effectiveness of the increase in the calcium in high blood pressure is most significant. The consumption of alkaline antioxidant water for a period of 2 to 3 months, I have observed the blood pressure slowly drop, due to the water’s solvent ability, which dissolves the cholesterol in the blood vessels.”

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Use of Ionized water for gynecological conditions

Prof. Watanabe Ifao, Watanabe Hospital “Ionized alklaine antioxidant water improves body constituents and ensures effective healing to many illnesses. The uses of antioxidant water in gynecological patients have proved to be very effective. The main reason for its effectiveness is that this water can neutralize toxins.When given antioxidant water to pre-eclamptic toxemia cases, the results are most significant. During my long years of servicing the pre-eclamptic toxemia cases, I found that the women with pre-eclamptic toxemia who consumed antioxidant water tend to deliver healthier babies with stronger muscles. A survey report carried out on babies in this group showed intelligence above average.”

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Toxin Neutralization

Prof. Kuwata Keijiroo, Doctor of MedicineIn my opinion, the wonder of antioxidant water is the ability neutralizes toxins, but it is not a medicine. The difference is that the medicine can only apply to each and individual case, whereas the antioxidant water can be consumed generally and its neutralizing power is something which is very much unexpected. Now, in brief, let me introduce to you a heart disease case and how it was cured.The patient was a 35 years old male suffering from vascular heart disease. For 5 years, his sickness deteriorated. He was in the Setagays Government Hospital for treatment.

During those 5 years, he had been in and out of the hospital 5 to 6 times. He had undergone high tech examinations such as angiogram by injecting VINYL via the vein into the heart. He consulted and sought treatment from many good doctors where later he underwent a major surgical operation. Upon his discharge from the hospital, he quit his job to convalesce. However, each time when his illness relapsed, the attack seemed to be even more severe. Last year, in August, his relatives were in despair and expected he would not live much longer. It so happened at that time that the victim’s relative came across antioxidant water processor. His illness responded well and he is now on the road to recovery.”

(In the United States, cardiovascular diseases account for more than one-half of the approximate 2 million deaths occurring each year…. It is estimated that optimal conditioning of drinking water could reduce this cardiovascular disease mortality rate by as much as 15 percent in the United States) – Report of the Safe Drinking Water Committee of the National Academy of Sciences, 1977

Denna information är framtagen från olika källor såsom forskningsinstitut men även från olika internetsidor Den är endast i utbildande syfte och är inte menad att behandla eller läka någon sjukdom eller symtom. Konsultera med din läkare för att få medicinska råd i ämnet.

Eczema

Prof. Tamura Tatsuji, Keifuku Rehabilitation Center

“Eczema is used to describe several varieties of skin conditions, which have a number of common features. The exact cause or causes of eczema are not fully understood. I many cases, eczema can be attributed by external irritants.Let me introduce a patient who recovered from skin disease after consuming the antioxidant water. This patient suffered 10 years of eczema and could not be cured effectively even under specialist treatment. This patient, who is 70 years of age, is the president of a vehicle spare parts company. After the war, his lower limbs suffered acute eczema, which later became chronic. He was repeatedly treated in a specialist skin hospital.

The left limb responded well to treatment, but not so on the right limb. He suffered severe itchiness, which, when scratched led to bleeding. During the last 10 years, he was seen and treated by many doctors. When I first examined him, his lower limb around the joints was covered with vesicles. Weeping occurred owing to serum exuding from the vesicles.